Skip to main content

Advertisement

Table 2 Removal capabilities of investigated blood purification device per mediator. Means expressed ± SD

From: In vitro comparison of the adsorption of inflammatory mediators by blood purification devices

  Mediators Removal rates (RR%) at 120 min
Control tubing oXiris CytoSorb Toraymyxin
Pro-inflammatory cytokines IL-3 3.9 (± 1.4) 99.3 (± 0.0) 99.4 (± 0.0) 70.2 (± 11.1)
IP-10 16.6 (± 17.4) 99.3 (± 0.3) 99.1 (± 0.2) 68.6 (± 11.9)
IL-17α 16.7 (± 7.8) 98.7 (± 0.4) 97.6 (± 0.3) 74.0 (± 6.2)
MIP-1α 2.9 (± 3.1) 97.3 (± 0.4) 97.3 (± 0.4) 91.0 (± 0.4)
MIP-1β 4.7 (± 2.9) 91.5 (± 1.2) 92.4 (± 0.0) 70.3 (± 9.0)
HMGB-1 8.4 (± 3.2) 89.5 (± 0.4) 91.8 (± 0.9) 61.5 (± 1.9)
IL-8 4.6 (± 8.0) 100 (± 0.0) 100 (± 0.0) 34.5 (± 13.1)
IFN-γ 7.9 (± 8.8) 99.5 (± 0.3) 95.7 (± 0.6) 37.4 (± 8.3)
Eotaxin 14.3 (± 9.1) 99.1 (± 0.1) 99.0 (± 0.0) 42.2 (± 7.9)
IL-6 5.2 (± 9.3) 93.5 (± 1.4) 99.6 (± 0.1) 41.8 (± 14.6)
MIF 14.3 (± 5.9) 78.0 (± 24.4) 83.0 (± 20.2) 45.1 (± 13.8)
MCP-1 6.0 (± 4.1) 100 (± 0.0) 100 (± 0.0) 11.3 (± 4.4)
TNF-α 11.8 (± 12.5) 90.1 (± 2.2) 98.4 (± 0.2) 17.9 (± 9.2)
IL-1β 8.2 (± 4.5) 86.8 (± 1.0) 97.2 (± 0.0) 15.0 (± 13.3)
Anti-inflammatory cytokines IL-4 6.1 (± 8.3) 99.9 (± 0.0) 99.9 (± 0.0) 55.9 (± 16.0)
IL-2 1.8 (± 5.0) 99.4 (± 0.2) 99.3 (± 0.3) 61.6 (± 13.6)
IL-10 8.9 (± 7.7) 99.0 (± 0.4) 99.8 (± 0.0) 40.6 (± 14.9)
IL-13 12.2 (± 5.9) 93.5 (± 0.0) 94.2 (± 0.0) 73.7 (± 20.6)
IL-1Ra 11.2 (± 3.6) 90.2 (± 2.8) 92.1 (± 0.0) 35.4 (± 16.2)
IL-12 p70 7.0 (± 7.5) 22.1 (± 4.5) 76.5 (± 2.5) 6.9 (± 8.0)
Complement factors C3a 14.8 (± 11.5) 96.4 (± 1.2) 98.2 (± 0.2) 67.9 (± 7.5)
C5a 1.3 (± 4.8) 90.7 (± 0.6) 95.7 (± 1.2) 38.8 (± 7.9)
Serine protease PAI-1 8.5 (± 4.9) 87.9 (± 1.8) 95.5 (± 0.4) 30.9 (± 9.6)
Growth factors FGF-23 18.3 (± 12.2) 98.7 (± 1.1) 99.4 (± 0.8) 88.4 (± 5.5)
FGF-21 2.9 (± 0.5) 96.0 (± 0.9) 99.9 (± 0.0) 70.9 (± 10.1)
G-CSF 8.1 (± 9.0) 36.0 (± 2.9) 99.4 (± 0.0) 16.9 (± 8.0)
Fluid removal CRRT Yes No No
  1. Abbreviations: C complement, CRRT continuous renal replacement therapy, FGF fibroblast growth factor, G-CSF granulocyte colony-stimulating factor (glycoprotein), HMGB-1 high-mobility group box 1 protein, IL interleukin, IFN interferon, IP interferon-induced protein, LPS lipopolysaccharide, MCP monocyte chemoattractant protein, MIF macrophage migration inhibitory factor, MIP macrophage inflammatory protein, PAI plasminogen activator inhibitor, SD standard deviation, TNF tumor necrosis factor, Ra receptor agonist, α alpha, β beta, γ gamma