Table 2 Removal capabilities of investigated blood purification device per mediator. Means expressed ± SD
From: In vitro comparison of the adsorption of inflammatory mediators by blood purification devices
Mediators | Removal rates (RR%) at 120 min | ||||
|---|---|---|---|---|---|
Control tubing | oXiris | CytoSorb | Toraymyxin | ||
Pro-inflammatory cytokines | IL-3 | 3.9 (± 1.4) | 99.3 (± 0.0) | 99.4 (± 0.0) | 70.2 (± 11.1) |
IP-10 | 16.6 (± 17.4) | 99.3 (± 0.3) | 99.1 (± 0.2) | 68.6 (± 11.9) | |
IL-17α | 16.7 (± 7.8) | 98.7 (± 0.4) | 97.6 (± 0.3) | 74.0 (± 6.2) | |
MIP-1α | 2.9 (± 3.1) | 97.3 (± 0.4) | 97.3 (± 0.4) | 91.0 (± 0.4) | |
MIP-1β | 4.7 (± 2.9) | 91.5 (± 1.2) | 92.4 (± 0.0) | 70.3 (± 9.0) | |
HMGB-1 | 8.4 (± 3.2) | 89.5 (± 0.4) | 91.8 (± 0.9) | 61.5 (± 1.9) | |
IL-8 | 4.6 (± 8.0) | 100 (± 0.0) | 100 (± 0.0) | 34.5 (± 13.1) | |
IFN-γ | 7.9 (± 8.8) | 99.5 (± 0.3) | 95.7 (± 0.6) | 37.4 (± 8.3) | |
Eotaxin | 14.3 (± 9.1) | 99.1 (± 0.1) | 99.0 (± 0.0) | 42.2 (± 7.9) | |
IL-6 | 5.2 (± 9.3) | 93.5 (± 1.4) | 99.6 (± 0.1) | 41.8 (± 14.6) | |
MIF | 14.3 (± 5.9) | 78.0 (± 24.4) | 83.0 (± 20.2) | 45.1 (± 13.8) | |
MCP-1 | 6.0 (± 4.1) | 100 (± 0.0) | 100 (± 0.0) | 11.3 (± 4.4) | |
TNF-α | 11.8 (± 12.5) | 90.1 (± 2.2) | 98.4 (± 0.2) | 17.9 (± 9.2) | |
IL-1β | 8.2 (± 4.5) | 86.8 (± 1.0) | 97.2 (± 0.0) | 15.0 (± 13.3) | |
Anti-inflammatory cytokines | IL-4 | 6.1 (± 8.3) | 99.9 (± 0.0) | 99.9 (± 0.0) | 55.9 (± 16.0) |
IL-2 | 1.8 (± 5.0) | 99.4 (± 0.2) | 99.3 (± 0.3) | 61.6 (± 13.6) | |
IL-10 | 8.9 (± 7.7) | 99.0 (± 0.4) | 99.8 (± 0.0) | 40.6 (± 14.9) | |
IL-13 | 12.2 (± 5.9) | 93.5 (± 0.0) | 94.2 (± 0.0) | 73.7 (± 20.6) | |
IL-1Ra | 11.2 (± 3.6) | 90.2 (± 2.8) | 92.1 (± 0.0) | 35.4 (± 16.2) | |
IL-12 p70 | 7.0 (± 7.5) | 22.1 (± 4.5) | 76.5 (± 2.5) | 6.9 (± 8.0) | |
Complement factors | C3a | 14.8 (± 11.5) | 96.4 (± 1.2) | 98.2 (± 0.2) | 67.9 (± 7.5) |
C5a | 1.3 (± 4.8) | 90.7 (± 0.6) | 95.7 (± 1.2) | 38.8 (± 7.9) | |
Serine protease | PAI-1 | 8.5 (± 4.9) | 87.9 (± 1.8) | 95.5 (± 0.4) | 30.9 (± 9.6) |
Growth factors | FGF-23 | 18.3 (± 12.2) | 98.7 (± 1.1) | 99.4 (± 0.8) | 88.4 (± 5.5) |
FGF-21 | 2.9 (± 0.5) | 96.0 (± 0.9) | 99.9 (± 0.0) | 70.9 (± 10.1) | |
G-CSF | 8.1 (± 9.0) | 36.0 (± 2.9) | 99.4 (± 0.0) | 16.9 (± 8.0) | |
Fluid removal | CRRT | – | Yes | No | No |