Table 3 Feasibility and clinical outcomes
From: Allostasis and sedation practices in intensive care evaluation: an observational pilot study
Clinical outcome | SPICE-II -standard sedation limb (n = 16) | All-SPICE OPS (n = 12) | P value |
|---|---|---|---|
Time from eligibility to enrolment (h), median [IQR] | 1.1 [0.44–3.54] | 1.4 [0.36–9.19] | P = 0.71 |
Time from eligibility to first blood draw (h), median [IQR] | 4.79 [2.0–10.61] | ||
Time from enrolment to first blood draw (h), median [IQR] | 0.655 [0.23–2.353] | ||
Samples obtained, % (n) | 89.2% (107/120) | ||
Interval from planned to actual sample draw time (h), median (IQR) | 0.0 (0–0.3) | ||
RASS − 2 to 1 first 48 h (%) | 38% (74/197) | 56% (33/59) | 0.016* |
RASS − 3 to − 5 first 48 h (%) | 57% (112/197) | 41% (24/59) | 0.037* |
Extubated within 7 days | 75% (12) | 75% (9) | > 0.999 |
Ventilator free days at day 28, mean (SD) | 20.1 (10.1) | 20.07 (9.66) | > 0.999 |
ICU LOS days, median [IQR] | 7.0 [2.5–9.4] | 6.45 [4.44] | 0.471 |
ICU mortality, % (n) | 12.5% (2) | 8% (1) | 0.7423 |
Hospital LoS, median [IQR] | 17.0 [4.0–29.0] | 21.15 [11.5–37.5] | 0.341 |
Hospital mortality, % (n) | 12.5 (2/16) | 16.67 (2/12) | > 0.999 |
90-day mortality, % (n) | 12.5 (2/16) | 16.67 (2/12) | > 0.999 |