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Intensive Care Medicine Experimental
Fig. 3 | Intensive Care Medicine Experimental

Fig. 3

From: A research pathway for the study of the delivery and disposition of nebulised antibiotics: an incremental approach from in vitro to large animal models

Fig. 3

Schematic diagram demonstrating the principle of lung microdialysis. The unidirectional perfusate flow provides a concentration gradient for diffusion of analytes across a semi-permeable membrane placed in the lung interstitium. The dialysate is then collected in microvials for analysis. a Principles of lung microdialysis with nebulised antibiotics—showing higher antibiotic concentration in the alveoli. b Principles of lung microdialysis with intravenous antibiotics—showing higher antibiotic concentration in the pulmonary arteriole

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