A research pathway for the study of the delivery and disposition of nebulised antibiotics: an incremental approach from in vitro to large animal models

Intensive Care Medicine Experimental

Table 2 Comparative characteristics between tobramycin 40 and 100 mg/ml solutions

Parameters	Tobramycin 40 mg/ml	Tobramycin 100 mg/ml
pH 88	6.88	6.99
Viscosity (centipoise)	1.58	2.12
Duration of nebulisation (min)
Endotracheal tube	7.88 ± 1.08	18.56 ± 2.36*
Tracheostomy tube	12 ± 1.4	14.63 ± 1.14*
Dv₁₀ (μm)	1.0 ± 0.05	1.4 ± 0.04
VMD (μm)	1.8 ± 0.2	2.1 ± 0.08
Dv₉₅ (μm)	5.7 ± 0.2	3.6 ± 0.8
FPF (%)	82.3 ± 6	99.44 ± 0.3*
Lung dose (mg)	39.2 ± 1.1	132.7 ± 12.6*

dv₁₀ volume diameter under which 10% of the sample resides; VMD volume median diameter under which 50% of the particles resides; dv₉₅ volume diameter under which 95% of the sample resides; FPF fine particle fraction (1–5 μm)
*p < 0.05