Fig. 1

Kaplan-Meier survival curves (a) and body temperature over time in sham, moderate, or severe CLP mice (b), temperature (c), and change in temperature (d) over time in survivors vs. non-survivors, and ROC analyses of last body temperature (e) and change in body temperature (f) as predictors of death in septic mice. Data are presented as mean ± SEM from six independent experiments representing a total number of n = 18 sham, n = 23 moderate CLP, and n = 17 severe CLP mice; *p < 0.05, **p < 0.01, ***p < 0.001 (vs. sham in (a, b)), ^#p < 0.05, ^##p < 0.01, ^###p < 0.001 vs. moderate CLP, by two-way ANOVA (or by Mantel-Cox log-rank test in (a) or t test in (d)). Note: Only two mice undergoing severe CLP survived past 18 h, therefore statistical analyses were not performed at this time-point in (b); similarly in (c), time-points past 18 h lacked sufficient n in the CLP non-survivors group to perform comparisons, and therefore are not included. Dotted line in (e, f) represents the line of identity for statistical comparison in ROC analyses. AUC area under the curve, 95% CI 95% confidence interval