Table 1 Modified MSS scoring system for monitoring of surrogate endpoints and assessment of disease severity in mouse CLP sepsis, adapted from Shrum et al. [4]
Murine Sepsis Score (MSS) | ||||
|---|---|---|---|---|
Score | 0 | 1 | 2 | 3 |
Appearance | Smooth coat | Slightly ruffled fur | Majority of fur on back is ruffled | Piloerection, puffy appearance |
Level of consciousness | Active | Active, avoids standing upright | Active only when provoked | Non-responsive, even when provoked |
Activity | Normal | Suppressed eating, drinking, or running | Stationary | Stationary, even when provoked |
Response to stimulus | Normal | Slowed response to auditory or touch stimuli | No response to auditory, slowed response to touch | No response to touch stimuli |
Eyes | Open | Not fully open, potentially secretions | Half closed, potential secretions | Mostly or completely closed |
Respiration quality | Normal | Periods of labored breathing | Consistently labored breathing | Labored breathing with gasps |