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Table 2 Modified M-CASS scoring system for monitoring of surrogate endpoints and assessment of disease severity in mouse CLP sepsis, adapted from Huet et al. [5]

From: Body temperature and mouse scoring systems as surrogate markers of death in cecal ligation and puncture sepsis

Mouse Clinical Assessment Score for Sepsis (M-CASS)

Score

0

1

2

3

Fur aspect

Normal coat

Slightly ruffled fur

Ruffled fur

Ruffled fur and piloerection

Activity

Normal

Reduced

Only when provoked

Little or none with provocation

Posture

Normal

Hunched, moving freely

Hunched, strained or stiff movement

Hunched, little or no movement

Behavior

Normal

Slow

Abnormal when disturbed or provoked

Abnormal, no relocation

Chest movements

Normal

Mild dyspnea

Moderate dyspnea

Severe dyspnea

Eyelids

Normal, open

Opened when disturbed

Partially closed, even when disturbed

Mostly or completely closed, even when provoked