A new way of monitoring mechanical ventilation by measurement of particle flow from the airways using Pexa method in vivo and during ex vivo lung perfusion in DCD lung transplantation

Intensive Care Medicine Experimental

Table 1 Shows total particle count for the different particle sizes from 1 to 8 during in vivo ventilation.

	In vivo
	VCV versus PVC			Small tidal volumes versus large tidal volumes		Low PEEP versus high PEEP
	VCV¹	PCV¹	p value	VCV²	p value	PCV²	PCV³	p value
Particle 1	1650 ± 277	11,543 ± 3044	0.02*	6300 ± 1197	0.003**	18,428 ± 3044	15,387 ± 2350	n.s.
Particle 2	992 ± 208	7521 ± 2099	0.03*	4238 ± 793	0.002**	12,580 ± 1288	10,743 ± 1983	n.s.
Particle 3	1683 ± 286	10,455 ± 2481	0.06	4948 ± 918	0.009**	15,125 ± 2069	15,245 ± 1937	n.s.
Particle 4	1233 ± 159	7208 ± 651	0.01*	4130 ± 955	0.019*	6066 ± 1299	10,003 ± 2331	n.s.
Particle 5	138 ± 28	3025 ± 437	0.02*	1345 ± 390	0.029*	3890 ± 1944	3025 ± 1151	n.s.
Particle 6	350 ± 32	3766 ± 476	0.01*	1552 ± 370	0.028*	4245 ± 1461	3570 ± 1029	n.s.
Particle 7	175 ± 56	2018 ± 259	0.01*	1255 ± 451	0.046*	2137 ± 762	1723 ± 735	0.008*
Particle 8	92 ± 20	2293 ± 376	0.02*	1053 ± 485	n.s.	2133 ± 1059	1426 ± 687	n.s.

VCV1 volume-controlled ventilation with small tidal volumes and PEEP at 2, VCV2 volume-controlled ventilation with large tidal volumes and PEEP at 2, PCV1 pressure-controlled ventilation with small tidal volumes and PEEP at 2, PCV2 pressure-controlled ventilation with large tidal volumes and PEEP at 2, PCV3 pressure-controlled ventilation with big tidal volumes and PEEP at 10
Significance was defined as: p < 0.01 (**), p < 0.05 (*), and p > 0.05 (not significant, n.s.)