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Fig. 4 | Intensive Care Medicine Experimental

Fig. 4

From: Time course of liver mitochondrial function and intrinsic changes in oxidative phosphorylation in a rat model of sepsis

Fig. 4

Mitochondrial proton permeability and basal oxygen consumption. Basal proton leak in liver mitochondria from matching sham-operated control (open symbols n = 6) and CLP rats (closed symbols n = 6), at 6, 24, 36 h after surgery (ac). Respiration and membrane potential were measured in the presence of oligomycin, nigericin, rotenone, and succinate as described in “Materials and methods” section. Sequential addition of malonate up to 3 mM was performed to induce variations in membrane potential. Values are means ± SEM from six different rats per group. d Liver mitochondria oligomycin-insensitive respiration of control (naïve and matching sham-operated) (white bars), and CLP rats (black bars). Data are means ± SEM. *p < 0.05 versus sham-operated and naïve rats; ‡p < 0.05 compared 6 h CLP and 24 h CLP; †p < 0.05 compared 6 h CLP and 36 h CLP, §p < 0.05 compared matching sham- operated control and naïve (control 0 h) rats; from six animals per group determined by surgical procedure and following period (0, 6, 24, 36 h)

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