Table 1 Characteristics of the pigs by study group. Data are presented as the median (interquartile range)
From: Heparin-binding protein in ventilator-induced lung injury
Control n = 6 | VILI n = 6 | p value | |
|---|---|---|---|
Weight (kg) | 35.5 (28–50) | 35.5 (29–47) | 0.818 |
Premature death (n) | 0 | 2 | |
Tidal volume (ml) | 280 (228–400) | 710 (575–940) | 0.002* |
Respiratory rate (breaths/min) | 30 (26–38) | 20 (20–20) | 0.002* |
Average peak inspiratory pressure (cmH2O) | 22 (20–23) | 43(39–48) | 0.002* |
FiO2 | 0.35 (0.29–0.40) | 1.0 (1.0–1.0) | 0.002* |
Worst P/F ratio (kPa) | 46 (34–52) | 14 (8–39) | 0.041* |
Last P/F ratio | 53 (43–64) | 25 (8–43) | 0.065 |
Last PCO2 (kPa) | 4.6 (3.8–5.0) | 5.9 (4.7–7.0) | 0.093 |
Last pH | 7.52 (7.47–7.55) | 7.41 (7.31–7.48) | 0.026* |
Total crystalloid (ml) | 2000 (975–3000) | 2500 (1800–3200) | 0.394 |
Total colloid (ml) | 0 (0–500) | 375 (0–500) | 0.485 |
Average fluid admin. (ml/kg/h) | 7.7 (4.4–8.2) | 10.0 (8.5–12.0) | 0.026* |
Average CVP (mmHg) | 8 (7–8) | 7 (6–9) | 0.394 |
Average MAP (mmHg) | 70 (67–75) | 75 (53–102) | 0.24 |
Average heart rate (bpm) | 87 (82–95) | 103 (94–111) | 0.065 |
Average temp (°C) | 39.4 (38.3–39.7) | 38.5 (38.0–39.3) | 0.394 |
Recovered BALF volume (%) | 78 (62.5–84.0) | 71 (60.0–79.0) | 0.168 |