Table 1 Drugs Studied
Drug | Final concentrations and/or volume (solvent for dilution) | Infusion flow rate | Time of infusion |
|---|---|---|---|
Norepinephrine Noradrénaline Mylan 2 mg/mL batch H2028 | 24 mg/48 mL (5% glucose) | 4 mL/h | Over 6 h (start in 1st position) |
Midazolam Midazolam Mylan 5 mg/mL batch F3108 | 100 mg/50 mL (0.9% sodium chloride solution) | 10 mL/h | Over 6 h (start in 2nd position) |
Sufentanil Sufentanil Mylan 5mcg/mL batch H3093 | 250 μg/50 mL (0.9% sodium chloride solution) | 4 mL/h | Over 6 h (start in 3rd position) |
Heparin Héparine sodique Panpharma 5000UI/mL batch 70577 | 5000ui/50 mL (0.9% sodium chloride solution) | 4 mL/h | Over 6 h (start in 4th position) |
5% Glucose Glucose Baxter 5% batches 18A08G64 and 17L19T4A | 500 mL | 20.8 mL/h | Over 6 h (start in 5th position) |
Binary PN Olimel N7 Baxter batch 17CON950 | 1200 mL for amino acid and glucose solutions | 62.5 mL/h | Over 6 h (start in 6th position) |
Omeprazole Oméprazole Mylan 40 mg batch T523 | 40 mg/50 mL (5% glucose) | 100 mL/h | T0 + 3 h (30 min) |
Piperacillin/Tazobactam Piperacilline tazobactam Mylan 4 g/0.5 g batch 5M2832FR | 4 g/100 mL (5% glucose) | 200 mL/h | T0 + 3 h30 (30 min) |
Fluconazole Fluconazole Kabi 2 mg/mL batch 5LA229F5 | 400 mg/200 mL | 400 mL/h | T0 + 4 h (30 min) |