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Table 2 Clinical and microbiology variables among study treatments

From: Appraisal of systemic inflammation and diagnostic markers in a porcine model of VAP: secondary analysis from a study on novel preventive strategies

Parameter

Time of assessment

Control (6)

EFB + PEEP (7)

Trendelenburg (7)

p value

Body temperature (Ā°C)

Throughout study time

37.0ā€‰Ā±ā€‰1.6

38.4ā€‰Ā±ā€‰2.1

37.1ā€‰Ā±ā€‰1.3

<ā€‰0.001

72Ā h

37.5ā€‰Ā±ā€‰0.9

39.6ā€‰Ā±ā€‰0.8

36.7ā€‰Ā±ā€‰1.3

White blood cells (Ɨā€‰109/L)

Throughout study time

17.2ā€‰Ā±ā€‰6.8

13.4ā€‰Ā±ā€‰4.3

17.7ā€‰Ā±ā€‰5.9

0.133

72Ā h

17.3ā€‰Ā±ā€‰7.5

12.7ā€‰Ā±ā€‰6.1

18.1ā€‰Ā±ā€‰2.8

PaO2/FIO2 (mmHg)

Throughout study time

424.8ā€‰Ā±ā€‰88.9

423.3ā€‰Ā±ā€‰76.5

443.6ā€‰Ā±ā€‰43.3

0.312

72Ā h

378.0ā€‰Ā±ā€‰85.0

339.1ā€‰Ā±ā€‰26.5

437.0ā€‰Ā±ā€‰40.6

CPIS

72Ā h

4.6ā€‰Ā±ā€‰0.9

6.3ā€‰Ā±ā€‰0.5

4.6ā€‰Ā±ā€‰0.9

0.035

Tracheal aspirate P. aeruginosa quantitative culture (log10 cfu/mL)

72Ā h

5.9ā€‰Ā±ā€‰1.1

6.0ā€‰Ā±ā€‰0.9

5.6ā€‰Ā±ā€‰1.0

0.487

  1. Data are reported as meanā€‰Ā±ā€‰standard deviation of various assessments throughout the study time or only at 72Ā h. Per each group, number of studied animals are reported between parenthesis. Of note, we report analyses p values of only the values of CPIS and tracheal aspirate P. aeruginosa quantitative culture at 72Ā h, whereas for the remaining parameters, we report p values of analysis of all assessed parameters throughout the study time (0, 24, 48, and 72Ā h). CPIS was computed as reported in the Table 1. PaO2/FIO2 arterial partial pressure of oxygen/inspiratory fraction of oxygen ratio, CPIS clinical pulmonary infection score, EFB + PEEP expiratory flow bias and positive end expiratory pressure group