Appraisal of systemic inflammation and diagnostic markers in a porcine model of VAP: secondary analysis from a study on novel preventive strategies

Intensive Care Medicine Experimental

Table 3 Clinical and microbiology variables between animals with or without VAP

Parameter	Time of assessment	No-VAP (10)	VAP (10)	p value
Body temperature (°C)	Throughout study time	37.2 ± 1.6	37.9 ± 1.9	0.592
Body temperature (°C)	72 h	37.2 ± 1.6	38.8 ± 1.1	0.592
White blood cells (× 10⁹/L)	Throughout study time	16.8 ± 5.6	15.3 ± 6.4	0.420
White blood cells (× 10⁹/L)	72 h	16.5 ± 4.1	15.2 ± 7.5	0.420
PaO₂/FIO₂ (mmHg)	Throughout study time	438.5 ± 58.5	390.5 ± 40.1	0.946
PaO₂/FIO₂ (mmHg)	72 h	430.4 ± 40.5	334.7 ± 47.7	0.946
CPIS	72 h	4.6 ± 0.9	5.8 ± 0.9	0.260
Tracheal aspirate P. aeruginosa quantitative culture (log₁₀ cfu/mL)	72 h	5.4 ± 1.0	6.3 ± 0.7	0.041

Data are reported as mean ± standard deviation of various assessments throughout the study time or only at 72 h. Per each group, number of studied animals are reported between parenthesis. Of note, we report analyses p values of only the values of CPIS and tracheal aspirate P. aeruginosa quantitative culture at 72 h, whereas for the remaining parameters, we report p values of analysis of all assessed parameters throughout the study time (0, 24, 48, and 72 h). CPIS was computed as reported in the Table 1. VAP ventilator-associated pneumonia, PaO₂/FIO₂ arterial partial pressure of oxygen/inspiratory fraction of oxygen ratio, CPIS clinical pulmonary infection score