Intravenous hydrogen sulfide does not induce neuroprotection after aortic balloon occlusion-induced spinal cord ischemia/reperfusion injury in a human-like porcine model of ubiquitous arteriosclerosis

Intensive Care Medicine Experimental

Table 3 Clinical evaluation of hind motor function during the experiment. MP measuring point

Group	MP1	MP2	MP3	MP4	MP5
Occlusion 30 min	3 + 4 (2 × [3 + 4] + 1 × 3)	1 (1 × 1 + 1 × 2)	2 (1 × 2 + 1 × 1 + 1 × 0)	3 + 4 (1 × [3 + 4] + 2 × 0)	3 + 4 (1 × [3 + 4] + 1 × 1 + 1 × 0)
Occlusion 40 min	3 + 4 (2 × [3 + 4])	0 (2 × 0)	0 (2 × 0)	3 (1 × 3 + 1 × 0)	2 (1 × 2 + 1 × 0)
NaCl (45 min)	3 + 4 (4 × [3 + 4])	2 (3 × 0 + 1 × 2)	2 (3 × 0 + 1 × 2)	2 (3 × 0 + 1 × 2)	2 (3 × 0 + 1 × 2)
Na₂S (45 min)	3 + 4 (4 × [3 + 4])	0 (4 × 0)	0 (4 × 0)	0 (4 × 0)	0 (4 × 0)

All animals showed normal function before aortic balloon occlusion. During reperfusion, only one animal in the sodium chloride group (n = 4) showed joint movement whereas all other pigs in the sodium sulfide (n = 4) group lost hind motor function. The data of the two groups with 30 min (n = 3) and 40 min (n = 2) occlusion time were obtained in preliminary experiments as described above. See text for details on the scoring system