Elevated plasma glypicans are associated with organ failure in patients with infection

Intensive Care Medicine Experimental

Table 1 Patient characteristics at time of blood sampling (baseline)

	Organ failure (n = 64, 35%)	No organ failure (n = 120, 65%)	p value*
Age, median (IQR)	65 (54–76)	53 (36–71)	0.005
Male, n (%)	38 (59%)	55 (46%)	0.080
Site of infection, n (%)
Respiratory tract	15 (23%)	63 (53%)	< 0.001
Urinary tract	19 (29%)	22 (18%)	0.078
Skin/soft tissue	14 (22%)	16 (13%)	0.135
Other	16 (26%)	19 (16%)	0.131
Infection agent, n (%)
Gram positive bacteria	23 (36%)	13 (11%)	< 0.001
Gram negative bacteria	19 (30%)	22 (18%)	0.078
Other bacteria	3 (5%)	12 (10%)	0.210
Virus	1 (2%)	37 (31%)	< 0.001
Unknown agent	18 (28%)	36 (30%)	0.790
Laboratory variables at baseline, median (IQR)
WBC (×10⁹ cells/L)	12 ± (6–19)	11 (8–14)	0.490
Temperature (°C)	38.9 (38.0–39.6)	38.5 (38–39)	0.018
Pulse (beats per minute)	105 (90–120)	90 (80–102)	< 0.001
Lactate (mM/L)	1.6 (1.2–2.4)	1.0 (0.8–1.4)	< 0.001
CRP (mg/L)	164 (107–235)	77 (26–182)	< 0.001
IL-6 (pg/mL)	493 (106–3300)	0 (0–73)	< 0.001
PCT (μg/L)	5.8 (1.5–15.6)	0.12 (0.05–0.5)	< 0.001

*Groups were compared by chi-square test (categorical variables) or by Mann Whitney U test (continuous variables)