Elevated plasma glypicans are associated with organ failure in patients with infection

Intensive Care Medicine Experimental

Table 3 Correlation of plasma GPC 1, 3 and 4 with plasma levels of markers of inflammation and disease severity, and with proteins associated with the glycocalyx

	GPC 1		GPC 3		GPC 4
	Spearman R	p value*	Spearman R	p value*	Spearman R	p value*
Disease severity markers
HBP	0.20	0.019	0.41	0.001	0.49	< 0.001
WBC	− 0.09	0.38	0.09	0.38	0.13	0.07
CRP	− 0.07	0.38	0.30	0.001	0.44	< 0.001
IL-6	0.18	0.056	0.37	0.001	0.47	< 0.001
Lactate	0.24	0.005	0.33	0.001	0.42	< 0.001
PCT	0.22	0.015	0.40	0.001	0.64	< 0.001
Glycocalyx components
SDC 1	0.16	0.061	0.35	0.001	0.38	< 0.001
GPC 1
GPC 3	0.46	0.002
GPC 4	0.25	0.002	0.56	0.001
Glycocalyx protective proteins
S1P	− 0.19	0.037	− 0.04	0.57	− 0.27	< 0.001
ApoM	− 0.10	0.056	− 0.39	0.001	− 0.54	< 0.001

*p values were determined by non-parametric Spearman correlation and adjusted for multiple comparisons by the Holm-Sidak method