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Intensive Care Medicine Experimental

Table 1 Body weight, oxygenation, blood pressure, and compliance during the mechanical ventilation

From: Angiotensin-(1–7) exerts a protective action in a rat model of ventilator-induced diaphragmatic dysfunction

 

Body weight (g)

PaO2 (mmHg)

Mean blood pressure (mmHg)

Respiratory system static compliance (ml/cmH2O)

Start

End

Start

End

CTRL

282 ± 34

–

–

–

0.44 ± 0.04

Vehicle

279 ± 32

94 ± 15

101 ± 22

91 ± 35

0.41 ± 0.03

0.33 ± 0.05

Ang-(1–7)

275 ± 37

100 ± 6

96 ± 18

91 ± 36

0.41 ± 0.08

0.32 ± 0.05

Ang-(1–7) + A-779

277 ± 30

91 ± 9

99 ± 16

95 ± 43

0.40 ± 0.06

0.32 ± 0.03

Ang-(1–7) + A-779 + PD

276 ± 16

102 ± 11

103 ± 25

139 ± 17*

0.42 ± 0.05

0.34 ± 0.05

ANOVA

NS

NS

NS

0.022

NS

NS

  1. CTRL (n = 10): unventilated controls; vehicle (n = 18): VIDD + saline treatment; Ang-(1–7) (n = 14): VIDD + Ang-(1–7) treatment; Ang-(1–7) + A-779 (n = 10): VIDD + Ang-(1–7) + A-779 treatment; Ang-(1–7) + A-779 + PD (n = 8): VIDD + Ang-(1–7) + A-779 + PD123319 treatment; *p = 0.018 vs Ang-(1–7), p = 0.044 vs Ang-(1–7) + A-779
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