From: Peroxynitrite decomposition catalyst reduces vasopressin requirement in ovine MRSA sepsis
Variables | Group | BL | ||||||
---|---|---|---|---|---|---|---|---|
0 h | 3 h | 6 h | 9 h | 12 h | 18 h | 24 h | ||
Core body temperature (°C) | AVP | 38.9 ± 0.1 | 40.1 ± 0.2 | 40.6 ± 0.1 | 40.3 ± 0.2 | 40.2 ± 0.1 | 40.1 ± 0.1 | 39.8 ± 0.2 |
WW-85 + AVP | 39.0 ± 0.1 | 40.0 ± 0.3 | 40.3 ± 0.3 | 40.1 ± 0.2 | 40.1 ± 0.2 | 40.3 ± 0.2 | 40.2 ± 0.2 | |
Heart rate (beats/min) | AVP | 85 ± 5 | 118 ± 14 | 151 ± 11 | 153 ± 12 | 135 ± 14 | 133 ± 10 | 130 ± 11 |
WW-85 + AVP | 93 ± 9 | 117 ± 8 | 134 ± 8 | 131 ± 11 | 123 ± 8 | 97 ± 7 | 100 ± 9 | |
Mean arterial pressure (mmHg) | AVP | 93.2 ± 1.7 | 96.3 ± 4.2 | 93.7 ± 2.9 | 88.2 ± 2.3 | 87.3 ± 3.0 | 94.0 ± 3.1 | 92.7 ± 4.7 |
WW-85 + AVP | 90.0 ± 1.2 | 90.3 ± 2.2 | 91.1 ± 2.0 | 89.7 ± 1.9 | 86.7 ± 1.9 | 91.7 ± 3.2 | 92.9 ± 3.0 | |
Mean pulmonary artery pressure (mmHg) | AVP | 18.2 ± 0.9 | 24.0 ± 1.2 | 25.3 ± 1.1 | 27.8 ± 1.5 | 29.7 ± 1.4 | 32.7 ± 1.9 | 31.8 ± 2.7 |
WW-85 + AVP | 19.0 ± 1.0 | 21.7 ± 1.3 | 23.7 ± 2.5 | 24.6 ± 1.2 | 27.0 ± 1.1 | 29.0 ± 1.9 | 27.6 ± 2.2 | |
Pulmonary artery wedge pressure (mmHg) | AVP | 9.5 ± 0.8 | 14.8 ± 0.9 | 15.2 ± 1.1 | 14.0 ± 0.9 | 14.5 ± 0.9 | 17.5 ± 0.7 | 18.0 ± 2.0 |
WW-85 + AVP | 10.4 ± 1.3 | 13.1 ± 1.2 | 12.6 ± 1.1 | 13.9 ± 1.6 | 15.7 ± 0.8 | 16.6 ± 1.8 | 14.3 ± 1.2 | |
Central venous pressure (mmHg) | AVP | 6.0 ± 0.7 | 8.7 ± 0.6 | 8.8 ± 1.0 | 10.3 ± 1.2 | 12.0 ± 1.4 | 14.7 ± 2.0 | 15.5 ± 1.7 |
WW-85 + AVP | 7.6 ± 0.8 | 7.4 ± 0.9 | 9.6 ± 1.8 | 10.3 ± 1.7 | 10.6 ± 1.9 | 11.9 ± 1.8 | 11.1 ± 1.6 | |
Systemic vascular resistance index (dynes/sec/cm5/m2) | AVP | 1270 ± 103 | 1187 ± 122 | 1172 ± 108 | 784 ± 100 | 731 ± 77 | 752 ± 76 | 764 ± 115 |
WW-85 + AVP | 1127 ± 106 | 1077 ± 118 | 1133 ± 153 | 1087 ± 141 | 1048 ± 148 | 1218 ± 233 | 1289 ± 267 | |
PaO2/FiO2 ratio (mmHg) | AVP | 487 ± 10 | 331 ± 58 | 336 ± 71 | 323 ± 71 | 260 ± 55 | 210 ± 34 | 190 ± 45 |
WW-85 + AVP | 496 ± 9 | 373 ± 33 | 402 ± 43 | 398 ± 49 | 360 ± 47 | 298 ± 52 | 264 ± 53 | |
Oxygenation index | AVP | 2.1 ± 0.1 | 3.7 ± 0.9 | 3.5 ± 0.7 | 4.9 ± 1.4 | 6.4 ± 1.8 | 12.3 ± 5.7 | 10.8 ± 3.1 |
WW-85 + AVP | 2.0 ± 0.1 | 2.8 ± 0.3 | 2.6 ± 0.3 | 2.9 ± 0.5 | 3.3 ± 0.6 | 7.0 ± 2.9 | 9.3 ± 4.3 | |
Peak airway pressure (cmH2O) | AVP | 20.3 ± 1.5 | 19.1 ± 1.0 | 19.7 ± 1.0 | 23.7 ± 2.3 | 25.8 ± 2.9 | 33.2 ± 5.2 | 31.7 ± 3.5 |
WW-85 + AVP | 19.6 ± 1.1 | 19.7 ± 1.0 | 19.4 ± 1.1 | 21.0 ± 1.3 | 20.9 ± 1.4 | 28.3 ± 3.1 | 28.3 ± 3.9 | |
Plateau airway pressure (cmH2O) | AVP | 18.0 ± 1.2 | 16.8 ± 0.7 | 16.7 ± 0.8 | 18.2 ± 1.8 | 21.5 ± 2.0 | 27.2 ± 4.8 | 27.8 ± 2.9 |
WW-85 + AVP | 17.0 ± 1.1 | 16.4 ± 1.0 | 16.1 ± 0.8 | 17.7 ± 1.2 | 17.6 ± 1.3 | 24.4 ± 2.8 | 25.4 ± 3.9 | |
Lung static compliance (mL/cmH2O) | AVP | 33.3 ± 3.0 | 35.9 ± 2.6 | 36.9 ± 3.5 | 35.3 ± 5.6 | 27.7 ± 4.3 | 22.8 ± 4.2 | 20.4 ± 3.6 |
WW-85 + AVP | 34.0 ± 3.4 | 35.5 ± 3.3 | 36.1 ± 3.1 | 32.6 ± 3.9 | 33.0 ± 3.7 | 23.3 ± 4.2 | 24.0 ± 4.7 | |
SvO2 (%) | AVP | 54.5 ± 3.9 | 67.9 ± 2.1 | 66.5 ± 3.4 | 66.7 ± 1.4 | 64.2 ± 4.9 | 65.2 ± 4.8 | 64.1 ± 4.9 |
WW-85 + AVP | 61.5 ± 2.1 | 74.8 ± 2.1 | 65.4 ± 2.7 | 65.5 ± 2.2 | 63.1 ± 2.1 | 54.4 ± 4.5 | 50.5 ± 5.3 | |
Glucose (mg/dL) | AVP | 55.0 ± 2.9 | 63.2 ± 2.5 | 40.2 ± 3.1 | 41.2 ± 4.9 | 37.2 ± 3.4 | 39.2 ± 4.5 | 35.0 ± 2.7 |
WW-85 + AVP | 67.8 ± 3.4 | 81.7 ± 11.9 | 46.7 ± 3.1 | 40.5 ± 2.3 | 43.0 ± 2.0 | 41.8 ± 4.8 | 41.8 ± 5.1 | |
Hematocrit (%) | AVP | 25.7 ± 1.1 | 26.7 ± 2.2 | 29.5 ± 2.0 | 27.3 ± 1.9 | 28.2 ± 2.3 | 27.2 ± 1.8 | 25.2 ± 1.7 |
WW-85 + AVP | 28.7 ± 1.3 | 25.7 ± 1.0 | 27.7 ± 1.4 | 26.4 ± 1.4 | 27.4 ± 1.7 | 27.3 ± 2.2 | 28.9 ± 1.7 |