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Table 1 Cardiovascular, respiratory, and biochemical variables during the baseline period and at 24 h of sepsis in two groups

From: Peroxynitrite decomposition catalyst reduces vasopressin requirement in ovine MRSA sepsis

Variables

Group

BL

0 h

3 h

6 h

9 h

12 h

18 h

24 h

Core body temperature (°C)

AVP

38.9 ± 0.1

40.1 ± 0.2

40.6 ± 0.1

40.3 ± 0.2

40.2 ± 0.1

40.1 ± 0.1

39.8 ± 0.2

WW-85 + AVP

39.0 ± 0.1

40.0 ± 0.3

40.3 ± 0.3

40.1 ± 0.2

40.1 ± 0.2

40.3 ± 0.2

40.2 ± 0.2

Heart rate (beats/min)

AVP

85 ± 5

118 ± 14

151 ± 11

153 ± 12

135 ± 14

133 ± 10

130 ± 11

WW-85 + AVP

93 ± 9

117 ± 8

134 ± 8

131 ± 11

123 ± 8

97 ± 7

100 ± 9

Mean arterial pressure (mmHg)

AVP

93.2 ± 1.7

96.3 ± 4.2

93.7 ± 2.9

88.2 ± 2.3

87.3 ± 3.0

94.0 ± 3.1

92.7 ± 4.7

WW-85 + AVP

90.0 ± 1.2

90.3 ± 2.2

91.1 ± 2.0

89.7 ± 1.9

86.7 ± 1.9

91.7 ± 3.2

92.9 ± 3.0

Mean pulmonary artery pressure (mmHg)

AVP

18.2 ± 0.9

24.0 ± 1.2

25.3 ± 1.1

27.8 ± 1.5

29.7 ± 1.4

32.7 ± 1.9

31.8 ± 2.7

WW-85 + AVP

19.0 ± 1.0

21.7 ± 1.3

23.7 ± 2.5

24.6 ± 1.2

27.0 ± 1.1

29.0 ± 1.9

27.6 ± 2.2

Pulmonary artery wedge pressure (mmHg)

AVP

9.5 ± 0.8

14.8 ± 0.9

15.2 ± 1.1

14.0 ± 0.9

14.5 ± 0.9

17.5 ± 0.7

18.0 ± 2.0

WW-85 + AVP

10.4 ± 1.3

13.1 ± 1.2

12.6 ± 1.1

13.9 ± 1.6

15.7 ± 0.8

16.6 ± 1.8

14.3 ± 1.2

Central venous pressure (mmHg)

AVP

6.0 ± 0.7

8.7 ± 0.6

8.8 ± 1.0

10.3 ± 1.2

12.0 ± 1.4

14.7 ± 2.0

15.5 ± 1.7

WW-85 + AVP

7.6 ± 0.8

7.4 ± 0.9

9.6 ± 1.8

10.3 ± 1.7

10.6 ± 1.9

11.9 ± 1.8

11.1 ± 1.6

Systemic vascular resistance index (dynes/sec/cm5/m2)

AVP

1270 ± 103

1187 ± 122

1172 ± 108

784 ± 100

731 ± 77

752 ± 76

764 ± 115

WW-85 + AVP

1127 ± 106

1077 ± 118

1133 ± 153

1087 ± 141

1048 ± 148

1218 ± 233

1289 ± 267

PaO2/FiO2 ratio (mmHg)

AVP

487 ± 10

331 ± 58

336 ± 71

323 ± 71

260 ± 55

210 ± 34

190 ± 45

WW-85 + AVP

496 ± 9

373 ± 33

402 ± 43

398 ± 49

360 ± 47

298 ± 52

264 ± 53

Oxygenation index

AVP

2.1 ± 0.1

3.7 ± 0.9

3.5 ± 0.7

4.9 ± 1.4

6.4 ± 1.8

12.3 ± 5.7

10.8 ± 3.1

WW-85 + AVP

2.0 ± 0.1

2.8 ± 0.3

2.6 ± 0.3

2.9 ± 0.5

3.3 ± 0.6

7.0 ± 2.9

9.3 ± 4.3

Peak airway pressure (cmH2O)

AVP

20.3 ± 1.5

19.1 ± 1.0

19.7 ± 1.0

23.7 ± 2.3

25.8 ± 2.9

33.2 ± 5.2

31.7 ± 3.5

WW-85 + AVP

19.6 ± 1.1

19.7 ± 1.0

19.4 ± 1.1

21.0 ± 1.3

20.9 ± 1.4

28.3 ± 3.1

28.3 ± 3.9

Plateau airway pressure (cmH2O)

AVP

18.0 ± 1.2

16.8 ± 0.7

16.7 ± 0.8

18.2 ± 1.8

21.5 ± 2.0

27.2 ± 4.8

27.8 ± 2.9

WW-85 + AVP

17.0 ± 1.1

16.4 ± 1.0

16.1 ± 0.8

17.7 ± 1.2

17.6 ± 1.3

24.4 ± 2.8

25.4 ± 3.9

Lung static compliance (mL/cmH2O)

AVP

33.3 ± 3.0

35.9 ± 2.6

36.9 ± 3.5

35.3 ± 5.6

27.7 ± 4.3

22.8 ± 4.2

20.4 ± 3.6

WW-85 + AVP

34.0 ± 3.4

35.5 ± 3.3

36.1 ± 3.1

32.6 ± 3.9

33.0 ± 3.7

23.3 ± 4.2

24.0 ± 4.7

SvO2 (%)

AVP

54.5 ± 3.9

67.9 ± 2.1

66.5 ± 3.4

66.7 ± 1.4

64.2 ± 4.9

65.2 ± 4.8

64.1 ± 4.9

WW-85 + AVP

61.5 ± 2.1

74.8 ± 2.1

65.4 ± 2.7

65.5 ± 2.2

63.1 ± 2.1

54.4 ± 4.5

50.5 ± 5.3

Glucose (mg/dL)

AVP

55.0 ± 2.9

63.2 ± 2.5

40.2 ± 3.1

41.2 ± 4.9

37.2 ± 3.4

39.2 ± 4.5

35.0 ± 2.7

WW-85 + AVP

67.8 ± 3.4

81.7 ± 11.9

46.7 ± 3.1

40.5 ± 2.3

43.0 ± 2.0

41.8 ± 4.8

41.8 ± 5.1

Hematocrit (%)

AVP

25.7 ± 1.1

26.7 ± 2.2

29.5 ± 2.0

27.3 ± 1.9

28.2 ± 2.3

27.2 ± 1.8

25.2 ± 1.7

WW-85 + AVP

28.7 ± 1.3

25.7 ± 1.0

27.7 ± 1.4

26.4 ± 1.4

27.4 ± 1.7

27.3 ± 2.2

28.9 ± 1.7

  1. The animal numbers in AVP groups is n = 6 and WW-85 + AVP group is n = 7. The data were analyzed by Two-way ANOVA repeated measurement with Bonferroni post-hoc test. Data are expressed as mean ± SEM. (* p<0.05 between two groups)