Extracorporeal membrane oxygenation (ECMO) and the acute respiratory distress syndrome (ARDS): a systematic review of pre-clinical models

Intensive Care Medicine Experimental

Table 1 Description of studies included in the systematic review

Study	Year	Species	Study type	Number	ARDS model type	ECMO configuration	Study duration (hours)
Kim et al. [18]	2004	Dog	Technology evaluation	16	Oleic acid	VA (central)	2
Araos et al. [12]	2016	Pig	Model development	18	Saline lavage + injurious ventilation	VV	24
Wang et al. [28]	2016	Pig	Interventional	28	LPS infusion	VV	24 + 14-day recovery
Ni et al. [23]	2015	Pig	Physiological	30	Blunt injury	VV	24
Pilarczyk et al. [25]	2015	Pig	Technology evaluation	14	Saline lavage	VV	8
Park et al. [24]	2013	Pig	Physiological	5	Saline lavage + fecal peritonitis	VV	Unclear
Kopp et al. [20]	2011	Pig	Technology evaluation	6	Hypoxia	VV	4
Song et al. [26]	2010	Pig	Interventional	28	LPS infusion	VV	24 + 7-day recovery
Kopp et al. [21]	2010	Pig	Technology evaluation	24	Saline lavage	VV	24
Henderson et al. [16]	2004	Pig	Interventional	24	Oleic acid	VA	8
Dembinski et al. [13]	2003	Pig	Technology evaluation	12	Saline lavage	VV	6
Kocyildrim et al. [19]	2017	Sheep	Interventional	11	LPS infusion	VV	4
Hou et al. [17]	2015	Sheep	Physiological	20	Hypoxia	VA (central)	unclear
Langer et al. [22]	2014	Sheep	Physiological	11	Oleic acid	VV	22
Shekar et al. [14]	2012	Sheep	Physiological	17	Smoke inhalation	VV	2–24
Totapally et al. [27]	2004	Sheep	Physiological	17	Saline lavage + HCL acid instillation	VA	6
Germann et al. [15]	1997	Sheep	Interventional	30	Oleic acid	VV (central)	5

LPS lipopolysaccharide, HCL hydrochloric acid, VA veno-arterial, VV veno-venous