Extracorporeal membrane oxygenation (ECMO) and the acute respiratory distress syndrome (ARDS): a systematic review of pre-clinical models

Millar, Jonathan E.; Bartnikowski, Nicole; von Bahr, Viktor; Malfertheiner, Maximilian V.; Obonyo, Nchafatso G.; Belliato, Mirko; Suen, Jacky Y.; Combes, Alain; McAuley, Daniel F.; Lorusso, Roberto; Fraser, John F.

doi:10.1186/s40635-019-0232-7

Intensive Care Medicine Experimental

Table 5 Details of ECMO management

From: Extracorporeal membrane oxygenation (ECMO) and the acute respiratory distress syndrome (ARDS): a systematic review of pre-clinical models

Study	ECMO type		ECMO equipment			ECMO settings			Anticoagulation
Study	Mode	Configuration	Pump	Oxygenator	Cannula size (Fr) A-R	Flow	Sweep gas	FiO₂	Type	ACT target (s)
Dogs
Kim et al. [18]	VAc	RA–Ao	Multiple	Multiple	23–19	1.2–2 L/min	1.8–2 L/min	0.6
Pigs
Araos et al. [12]	VV	EJV–EJV	Medtronic Bioconsole 540	Medos HILTE 2400LT	23 dual-lumen	65 mL/kg/min	65 mL/kg/min		Heparin	180–220
Wang et al. [28]	VV	EJV–FV	Maquet Jostra	Medos HILTE 2400LT	12–8	70–80 mL/kg/min		1.0	Heparin	180–220
Ni et al. [23]	VV	FV–IJV	Maquet Rotaflow	Maquet Quadrox D	14–14	50 mL/kg/min	50 mL/kg/min	1.0	Heparin	180–220
Pilarczyk et al. [25]	VV	FV–EJV	Multiple	Multiple	23–21	2.4–2.8 L/min	3 L/min		Heparin	180–220
Park et al. [24]	VV	FV - EVJ	Maquet Rotaflow	Maquet Quadrox D	20/21–20/21	0.5–3 L/min	2:1–1:2 BF:GF		Heparin	1.5–2.5 × baseline
Kopp et al. [20]	VV	FV–EJV	Experimental	Experimental	19–17	30–40% CO	2 L/min		Heparin	≥ 149
Song et al. [26]	VV	EVJ–FV	Maquet Jostra	Medos HILTE 2400LT	14–12	70–80 mL/kg/min	2 L/min	1.0	Heparin	180–220
Kopp et al. [21]	VV	FV – EVJ	Multiple	Multiple	Multiple	25–40% CO	3–6 L/min		Heparin	120–150
Henderson et al. [16]	VA	EJV–CA	Stockert roller pump		8–10	100 mL/kg/min			Heparin	180–220
Dembinski et al. [13]	VV	FV–FV	Medos DeltaStream	Medos HILTE 7000	17–15	30% CO	30% CO	1.0	Heparin	≥ 130
Sheep
Kocyildrim et al. [19]	VV	SVC–PA	Thoratec Centrimag	Xenios iLA	24–24	1.2–1.4 L/min			Heparin	> 200
Hou et al. [17]	VAc	Multiple	Maquet Rotaflow	Maquet Quadrox D	19–15	50 mL/kg/min	50 mL/kg/min	1.0	Heparin	180–220
Langer et al. [22]	VV	EJV–EJV	Maquet Cardiohelp	Maquet HLS Set	23 dual-lumen	2 L/min	1–10 L/min	0.5–1.0	Heparin	> 160
Shekar et al. [14]	VV	EJV–EJV	Maquet Rotaflow	Maquet Quadrox D	21–19	60–80 mL/kg/min	80% pump flow	1.0	Heparin	220–250
Totapally et al. [27]	VA	IJV–CA		Medtronic Minimax		15% CO	1 L/min	1.0	Heparin
Germann et al. [15]	VVc	IVC–SVC	Stockert roller pump	Medtronic Maxima+		2.5–3.5 L/min		0.21–1.0

Fr French, FiO2 inspired fraction of oxygen, A–R access–return, ACT activated clotting time, Vac central veno-arterial, RA right atrium, Ao aorta, VV veno-venous, EJV external jugular vein, FV femoral vein, IJV internal jugular vein, VA veno-arterial, CA carotid artery, SVC superior vena cava, PA pulmonary artery, VVc central veno-veno

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