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Table 6 Proposed domains of a minimum reporting standard for pre-clinical studies of ARDS and ECMO

From: Extracorporeal membrane oxygenation (ECMO) and the acute respiratory distress syndrome (ARDS): a systematic review of pre-clinical models

Domains

Example items

Notes

1. ARDS model and definition

Method of injury, including dosing and duration

Should be consistent with ATS report [38]

Description of validation

Operational definition of injury

2. Mechanical ventilation

Mode of ventilation

Target tidal volume

PEEP settings

Ventilatory strategy during ECMO

3. Supportive care

Use of neuromuscular blockade

Prone positioning

Fluid therapy–type and quantity

4. ECMO equipment

Pump and oxygenator make and model

Cannulae make and model

5. ECMO cannulation

Standard description of configuration

Should use Maastricht treaty nomenclature [46]

Method of cannulation

6. ECMO management

Flow targets

Gas exchange targets/sweep gas management

Anticoagulation strategy and targets