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Table 3 Randomized controlled studies in lung-protective ventilation and PaCO2 levels

From: The role of hypercapnia in acute respiratory failure

StudyMortality benefitPaCO2 in control arm (mmHg ± SD)PaCO2 in LPV arm (mmHg ± SD)Buffer used
ARDSNet [2]Yes35.8 ± 8.040.0 ± 10.0Yes
Amato et al. [66]Yes36.0 ± 1.558.0 ± 3.0No
Brochard et al. [46]No41.0 ± 7.559.5 ± 19.0No
Brower et al. [67]No40.1 ± 1.650.3 ± 3.5Yes
Stewart et al. [68]No46.1 ± 1054.5 ± 15No
  1. LPV lung-protective ventilation