The diagnostic accuracy for ARDS of global versus regional lung ultrasound scores - a post hoc analysis of an observational study in invasively ventilated ICU patients

Pisani, Luigi; Vercesi, Veronica; van Tongeren, Patricia S. I.; Lagrand, Wim K.; Leopold, Stije J.; Huson, Mischa A. M.; Henwood, Patricia C.; Walden, Andrew; Smit, Marry R.; Riviello, Elisabeth D.; Pelosi, Paolo; Dondorp, Arjen M.; Schultz, Marcus J.

doi:10.1186/s40635-019-0241-6

Intensive Care Medicine Experimental

Table 1 Patients baseline, ventilation, and outcome characteristics

From: The diagnostic accuracy for ARDS of global versus regional lung ultrasound scores - a post hoc analysis of an observational study in invasively ventilated ICU patients

	No ARDS	ARDS	P value	ARDS severity groups
	No ARDS	ARDS	P value	Mild	Moderate	Severe	P value
N	117	35		12	18	5
Demographics
Age—years	62 (51, 72)	58 (48, 69)	0.15	66 (52, 70)	57 (29, 69)	53 (46, 55)	0.201
Male—%	69 (59.0)	21 (60.0)	1	5 (41.7)	12 (66.7)	4 (80.0)	0.281
APACHE II	21 (17, 27)	20 (15, 26)	0.324	20 (16, 27)	20 (14, 24)	24 (20, 27)	0.708
APS	38 (15, 52)	39 (16, 55)	0.712	22 (15, 50)	27 (17, 54)	60 (54, 63)	0.333
SOFA	9 (7, 12)	11 (8, 13)	0.218	9 (7, 12)	11 (8, 13)	13 (12, 15)	0.043
Clinical insult^a
Sepsis—%	27 (23.1)	11 (31.4)	0.374	4 (33.3)	4 (22.2)	3 (60.0)	0.334
Pneumonia—%	17 (14.5)	17 (48.6)	< 0.001	7 (58.3)	9 (50.0)	1 (20.0)	0.426
Stroke—%	26 (22.2)	1 (2.9)	0.006	1 (8.3)	0 (0.0)	0 (0.0)	0.486
Surgery—%	24 (20.5)	4 (11.4)	0.321	1 (8.3)	2 (11.1)	1 (20.0)	0.620
Trauma—%	15 (12.8)	2 (5.7)	0.362	1 (8.3)	0 (0.0)	1 (20.0)	0.118
Other—%	26 (22.2)	9 (25.7)	0.653	2 (16.7)	7 (38.9)	0 (0.0)	0.210
Ventilation
PEEP—cm H2O	5 (5, 7)	10 (7, 12)	< 0.001	7 (6, 10)	10 (8, 14)	15 (10, 15)	0.014
PaO₂/FiO₂	315 (234, 380)	163 (124, 247)	< 0.001	255 (247, 278)	144 (125, 171)	73 (68, 81)	< 0.001
Pmax—mmHg	17 (14, 22)	28 (21, 31)	< 0.001	26 (22, 29)	29 (20, 33)	29 (27, 30)	0.446
RR—breaths per min	18 (14, 23)	27 (19, 32)	< 0.001	25 (21, 31)	29 (19, 33)	22 (12, 29)	0.692
FiO₂	0.30 (0.25, 0.40)	0.45 (0.34, 0.60)	< 0.001	0.30 (0.29, 0.33)	0.55 (0.42, 0.60)	1 (0.90, 1)	< 0.001
Minute volume—l/min	8.8 (7.2, 10.8)	10.8 (9.2, 13.3)	< 0.001	9.7 (9.2, 10.6)	12.5 (10.5, 13.3)	14.1 (6.9, 15.2)	0.233
T_V—ml/PBW	8.0 (6.6, 9.2)	6.9 (5.7, 9.3)	0.275	8.6 (6.6, 9.3)	6.9 (5.5, 9.4)	5.9 (3.5, 7.2)	0.279
Outcomes
Duration of MV—days	3 (1, 8)	9 (3, 18)	< 0.001	4 (2, 11)	12 (7, 18)	3 (2, 19)	0.131
ICU mortality—%	37 (31.6)	13 (37.1)	0.545	3 (25.0)	5 (27.8)	5 (100.0)	0.007
Hospital Mortality—%	47 (40.2)	13 (37.1)	0.845	3 (25.0)	5 (27.8)	5 (100.0)	0.007
Ventilator free days	19 (0, 24)	5 (0, 19)	0.038	16 (2, 21)	7 (0, 18)	0 (0, 0)	0.030

Values are presented as N(%) or median (interquartile range)
Ventilatory parameters refer to the moment of the lung ultrasound examination
APACHE Acute Physiology and Chronic Health Evaluation score, APS acute physiology score, SOFA sequential organ failure assessment score, ARDS acute respiratory distress syndrome, ICU intensive care unit, FiO₂ fraction of inspired oxygen, PEEP positive end-expiratory pressure, Pmax maximal inspiratory airway pressure, RR respiratory rate, TV tidal volume, PBW predicted body weight, SpO₂ pulse oximetry oxygen saturation, PaO₂ arterial partial pressure of oxygen
^aNon-exclusive categories

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