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Table 1 Results of aerosol dose across different drug delivery interfaces during simulated healthy adult and distressed breathing. LPM liters per minute, N/A not applicable. VMN does not require supplemental gas flow for normal operation. The values represented are mean ± standard deviation (expressed in percentage) of three independent experiments

From: Comparison of aerosol delivery across combinations of drug delivery interfaces with and without concurrent high-flow nasal therapy

 

Supplemental gas flow rate (LPM)

Aerosol dose (%)

Healthy adult breathing

Aerosol dose (%)

Distressed adult breathing

VMN + HFNT at 50LPM

N/A

2.88 ± 0.15

6.81 ± 0.45

Mask + VMN/Ultra

0LPM

3.43 ± 0.62

28.76 ± 1.72

2LPM

29.93 ± 0.46

35.47 ± 1.81

6LPM

22.44 ± 0.63

36.21 ± 0.78

Mask + VMN/Ultra + HFNT at 50LPM

0LPM

0.33 ± 0.07

0.86 ± 0.04

2LPM

1.62 ± 0.46

2.96 ± 0.26

6LPM

1.07 ± 0.25

4.23 ± 0.93

Mouthpiece + VMN/Ultra

0LPM

0.63 ± 0.07

1.92 ± 1.12

2LPM

28.72 ± 1.24

21.37 ± 0.78

6LPM

31.52 ± 0.35

28.46 ± 0.38

Mouthpiece + VMN/Ultra + HFNT at 50LPM

0LPM

0.56 ± 0.13

0.73 ± 0.37

2LPM

2.16 ± 0.06

0.97 ± 0.20

6LPM

1.82 ± 0.41

3.11 ± 0.53

Mask + JN

8LPM

6.13 ± 0.09

9.07 ± 0.26

Mask + JN + HFNT at 50LPM

8LPM

0.82 ± 0.16

5.72 ± 0.71

Mouthpiece + JN

8LPM

12.68 ± 1.16

12.90 ± 2.52

Mouthpiece + JN + HFNT at 50LPM

8LPM

0.86 ± 0.11

0.69 ± 0.53