The physiological determinants of near-infrared spectroscopy-derived regional cerebral oxygenation in critically ill adults

Intensive Care Medicine Experimental

Table 1 Demographics and clinical characteristics

Characteristic	Nested cohort (n = 43)
Median age (years, [IQR])	68 [58.5–79]
Male gender (no. [%])	29 [67]
Admitting diagnosis (no. [%]):
Respiratory failure	13 [30]
Severe sepsis/septic shock	7 [16]
Cardiac	7 [16]
Gastrointestinal	7 [16]
Vascular	4 [9]
Trauma	3 [7]
Neurological	0
Other*	2 [5]
APACHE score (median, IQR)	20 [16–26]
Co-morbidities (no. [%]):
Cardiac**	19 [44]
Hypertension	24 [56]
Respiratory***	14 [33]
Diabetes	11 [26]
Active tobacco use	11 [26]
Heavy alcohol use	5 [12]
At time of enrolment (no. [%]):
Intubated	41 [95]
Vasoactive agents	24 [56]
ICU LOS (median [IQR])	7 [4–13]
ICU mortality (no. [%])	7 [16]
Physiological variables (median [IQR]):
MAP (mmHg)	73.77 [71.04–80.84]
HR (bpm)	85.77 [73.82–99.79]
PaCO₂ (mmHg)	40.50 [35.20–44.75]
PaO₂ (mmHg)	86.25 [79.75–94.17]
pH (mmHg)	7.37 [7.33–7.42]
SpO₂ (%)	96.34 [95.23–97.52]
Hb (g/L)	102.67 [86.00–115.50]
rSO₂ (%)	68.41 [64.56–72.16]

MAP mean arterial pressure, HR heart rate, PaCO₂ arterial partial pressure of carbon dioxide, PaO₂ arterial partial pressure of oxygen, SpO₂ arterial oxygen saturation, Hb hemoglobin, rSO₂ regional cerebral oxygenation
*Other included the following: drug overdose/withdrawal and acute kidney injury
**Cardiac included the following: arrhythmia, prior myocardial infarction, prior cardiac arrest, known coronary artery disease, and/or congestive heart failure
***Respiratory included the following: asthma or COPD