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Intensive Care Medicine Experimental

Table 2 Ventilation settings for the ARDSnet groups 4–6

From: Time-controlled adaptive ventilation (TCAV) accelerates simulated mucus clearance via increased expiratory flow rate

Group no. Mode of ventilation (n = 10 runs/group)

I:E

VT (cc)

Ti (sec)

RR (breaths/min)

Flow (L/min)

PEEP (cmH2O)

4. ARDSnet protocol group 4

1:2

240

1.6

12

40

0

5. ARDSnet protocol group 5

1:2

240

1.6

12

40

10

6. ARDSnet protocol group 6

1:2

240

1.6

12

40

20

  1. Tidal volumes of 240 cc were chosen based on ARDSnet protocol; the standard 6 cc/kg was used in a calculation for a standard 40 kg pig. PEEP of 0, 10, and 20 cmH2O were chosen to reflect a progressive PEEP scale advocated by the ARDSnet protocol [11]. A maximum PEEP of 20cmH2O was chosen because this value generated a plateau pressure of ~ 25 cmH2O, most similar to the plateau pressure seen in the TCAV groups
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