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Table 2 Ventilation settings for the ARDSnet groups 4–6

From: Time-controlled adaptive ventilation (TCAV) accelerates simulated mucus clearance via increased expiratory flow rate

Group no. Mode of ventilation (n = 10 runs/group) I:E VT (cc) Ti (sec) RR (breaths/min) Flow (L/min) PEEP (cmH2O)
4. ARDSnet protocol group 4 1:2 240 1.6 12 40 0
5. ARDSnet protocol group 5 1:2 240 1.6 12 40 10
6. ARDSnet protocol group 6 1:2 240 1.6 12 40 20
  1. Tidal volumes of 240 cc were chosen based on ARDSnet protocol; the standard 6 cc/kg was used in a calculation for a standard 40 kg pig. PEEP of 0, 10, and 20 cmH2O were chosen to reflect a progressive PEEP scale advocated by the ARDSnet protocol [11]. A maximum PEEP of 20cmH2O was chosen because this value generated a plateau pressure of ~ 25 cmH2O, most similar to the plateau pressure seen in the TCAV groups