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Table 3 Primary and secondary outcomes recorded

From: Time-controlled adaptive ventilation (TCAV) accelerates simulated mucus clearance via increased expiratory flow rate

  TCAV, PLow 0 (standard) TCAV, PLow 5 TCAV, PLow 10 LTV, PEEP 0 LTV, PEEP 10 LTV, PEEP 20
Mucus movement (cm/min) 7.95 ± 0.49 5.83 ± 0.50 1.91 ± 0.25 0 ± 0 0 ± 0 0 ± 0
IPF (L/min) 44.04 ± 0.63 35.37 ± 0.48 28.88 ± 0.62 45.06 ± 0.42 44.68 ± 0.23 44.11 ± 0.96
EPF (L/min) 51.27 ± 0.45 46.84 ± 0.35 36.76 ± 0.44 32.94 ± 0.58 23.52 ± 0.21 23.16 ± 0.61
PIP (cmH2O) 25 ± 0 25 ± 0 25 ± 0 23.4 ± 0.72 26 ± 0.54 37.9 ± 0.23
PPlat (cmH2O) 24.9 ± 0.1 24.9 ± 0.1 25 ± 0 10.08 ± 0.10 15 ± 0 26.81 ± 0.7
PMean (cmH2O) 21.8 ± 0.13 22.8 ± 0.13 23 ± 0 4.45 ± 0.05 12.7 ± 0.15 23.4 ± 0.16
PEEP (cmH2O) N/A N/A N/A 0.57 ± 0.02 10 ± 0 20.2 ± 0.2
MV (L/min) 6.28 ± 0.15 4.01 ± 0.8 3.63 ± 0.12 3.01 ± 0.02 3.08 ± 0.03 3.13 ± 0.08
VT (cc) 491.6 ± 11.61 315.5 ± 3.15 271.56 ± 5.91 243.4 ± 1.65 245.3 ± 1.45 241.2 ± 0.36
  1. All values are reported in mean ± SE. TCAV time-controlled adaptive ventilation, LTV low tidal volume, IPF peak inspiratory flow, EPF peak expiratory flow, PIP peak inspiratory pressure, PPlat plateau pressure, PMean mean airway pressure, PEEP positive end-expiratory pressure, MV minute ventilation, VT tidal volume. Proximal mucus movement was significantly different between all groups (p < 0.05), except ARDSnet groups 4, 5, and 6. EPF was significantly different between all groups (p < 0.05), except ARDSnet groups 5 and 6. Regarding IPF, there was no significant difference between TCAV group 1 and ARDSnet groups 4, 5, and 6; however, groups 1, 4, 5, and 6 had significantly greater IPF than TCAV groups 2 and 3 (p < 0.05)