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Fig. 3 | Intensive Care Medicine Experimental

Fig. 3

From: Adrecizumab, a non-neutralizing anti-adrenomedullin antibody, improves haemodynamics and attenuates myocardial oxidative stress in septic rats

Fig. 3

Effect of Adrecizumab on the adrenomedullin pathway. a Adrenomedullin plasma level (pg / mL). bd Expression of adrenomedullin (ADM) mRNA and its receptors (CRLR, RAMP 1 and 2) in the heart, lungs, kidneys, and adrenals. These measurements were performed 3 h after the Adrecizumab injection and 24 h after the induction of sepsis. Kruskal-Wallis test followed by Dunn’s multiple comparison test was used. *p < 0.05 and ***p < 0.001

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