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Table 1 Septic shock patient characteristics at admission and molecular markers and outcomes according to viral DNAemia during the first week in ICU (excluding TTV)

From: Early herpes and TTV DNAemia in septic shock patients: a pilot study

  Viremia not present (n = 46) At least one herpes viremia event (n = 52) Whole cohort (n = 98) p value
Demographics
Gender (female) 10 (21.7) 23 (44.2) 33 (33.7) 0.03*
Age (years) 70 [61–75] 69 [57–78] 70 [59–77] 0.86
Admission data
 SAPS II 62 [49–72] 64 [56–74] 63 [52–72] 0.18
 SOFA score day 1 11 [8–13] 12 [10–14] 12 [9–14] 0.01*
 SOFA score day 3 8 [7–12] 11 [8–14] 9 [7–13] 0.02*
 SOFA score day 6 5 [4–8] 7 [5–11] 6 [4–10] 0.03*
 Hemofiltration 7 (15) 20 (38) 27 (28) 0.02*
 Charlson score 2 [1–4] 1 [0–2] 2 [1–3] 0.04*
Primary site of infection 0.19
 Pulmonary 27 (59) 26 (50) 53 (54)  
 Abdominal 12 (26) 10 (19) 22 (22)  
 Other 7 (15) 16 (31) 23 (23)  
Type of primary infection 0.14
 Community acquired 27 (59) 38 (73) 65 (66)  
 Hospital acquired 19 (41) 14 (27) 33 (34)  
Hydrocortisone 27 (60) 40 (78) 67 (70) 0.08
Chemistry and hematology at admission
 Plasma lactate level (mM) 2.3 [1.6–3.2] 2.9 [2.2–4.9] 2.6 [1.8–4.0] 0.02*
 Neutrophils (G/L) 8.4 [6.0–13.1] 12.0 [7.3–15.6] 9.9 [6.5–14.6] 0.17
 Lymphocytes (G/L) 0.6 [0.4–1.0] 0.8 [0.5–1.1] 0.7 [0.4–1.1] 0.33
 Monocytes (G/L) 0.4 [0.2–0.8] 0.3 [0.1–0.7] 0.4 [0.1–0.8] 0.29
Molecular markers
 CD74 ratio (D3/D1; CNRQ) 1.2 [0.8–1.6] 1.3 [0.7–1.7] 1.2 [0.7–1.7] 0.77
 CX3CR1 day 3 (CNRQ) 0.27 [0.15–0.52] 0.17 [0.08–0.29] 0.21 [0.10–0.38] < 0.01*
 IL10 day 3 (NRQ) 0.04 [0.03,0.06] 0.03 [0.02,0.06]] 0.04 [0.02,0.06] 0.22
 IL1β day 3 (CNRQ) 1.64 [1.11–2.39] 1.15 [0.87–1.82] 1.34 [1.05–2.14] < 0.01*
Outcomes
 Vasopressors duration (days) 2.9 [1.8–6.0] 3.4 [2.1–5.7] 3.1 [1.9–6.0] 0.66
 Hemofiltration duration (days) 4 [3–10] 4 [2–6] 4 [2–7] 0.55
 Mechanical ventilation (days) 9 [7–17] 11 [8–16] 11 [7–17] 0.45
 ICU length of stay (days) 13 [9–24] 16 [10–20] 14 [9–21] 0.21
 Hospital length of stay (days) 28 [16–53] 33 [19–59] 30 [19–54] 0.44
 ICU mortality 11 (24) 12 (23) 23 (23) 1.00
 Survival D28 35 (76) 42 (81) 77 (79) 0.75
 At least one IAI 11 (24) 14 (27) 25 (26) 0.91
  1. Categorical variables are expressed as n (%) and continuous variables as median [Q1–Q3]. Comparisons between “at least one viral event” and “no viral DNAemia” were performed with chi-squared test for qualitative variables and Mann-Whitney or t tests for quantitative variables, as appropriate. Values labeled with * indicate significance at p < 0.05. IAI ICU aquired infection, ICU intensive care unit, SAPSII simplified acute physiology score, SOFA sequential organ failure assessment, (C)NRQ PCR (calibrated) normalized relative quantities