Table 1 Septic shock patient characteristics at admission and molecular markers and outcomes according to viral DNAemia during the first week in ICU (excluding TTV)
From: Early herpes and TTV DNAemia in septic shock patients: a pilot study
Viremia not present (n = 46) | At least one herpes viremia event (n = 52) | Whole cohort (n = 98) | p value | |
|---|---|---|---|---|
Demographics | ||||
Gender (female) | 10 (21.7) | 23 (44.2) | 33 (33.7) | 0.03* |
Age (years) | 70 [61–75] | 69 [57–78] | 70 [59–77] | 0.86 |
Admission data | ||||
SAPS II | 62 [49–72] | 64 [56–74] | 63 [52–72] | 0.18 |
SOFA score day 1 | 11 [8–13] | 12 [10–14] | 12 [9–14] | 0.01* |
SOFA score day 3 | 8 [7–12] | 11 [8–14] | 9 [7–13] | 0.02* |
SOFA score day 6 | 5 [4–8] | 7 [5–11] | 6 [4–10] | 0.03* |
Hemofiltration | 7 (15) | 20 (38) | 27 (28) | 0.02* |
Charlson score | 2 [1–4] | 1 [0–2] | 2 [1–3] | 0.04* |
Primary site of infection | 0.19 | |||
Pulmonary | 27 (59) | 26 (50) | 53 (54) | |
Abdominal | 12 (26) | 10 (19) | 22 (22) | |
Other | 7 (15) | 16 (31) | 23 (23) | |
Type of primary infection | 0.14 | |||
Community acquired | 27 (59) | 38 (73) | 65 (66) | |
Hospital acquired | 19 (41) | 14 (27) | 33 (34) | |
Hydrocortisone | 27 (60) | 40 (78) | 67 (70) | 0.08 |
Chemistry and hematology at admission | ||||
Plasma lactate level (mM) | 2.3 [1.6–3.2] | 2.9 [2.2–4.9] | 2.6 [1.8–4.0] | 0.02* |
Neutrophils (G/L) | 8.4 [6.0–13.1] | 12.0 [7.3–15.6] | 9.9 [6.5–14.6] | 0.17 |
Lymphocytes (G/L) | 0.6 [0.4–1.0] | 0.8 [0.5–1.1] | 0.7 [0.4–1.1] | 0.33 |
Monocytes (G/L) | 0.4 [0.2–0.8] | 0.3 [0.1–0.7] | 0.4 [0.1–0.8] | 0.29 |
Molecular markers | ||||
CD74 ratio (D3/D1; CNRQ) | 1.2 [0.8–1.6] | 1.3 [0.7–1.7] | 1.2 [0.7–1.7] | 0.77 |
CX3CR1 day 3 (CNRQ) | 0.27 [0.15–0.52] | 0.17 [0.08–0.29] | 0.21 [0.10–0.38] | < 0.01* |
IL10 day 3 (NRQ) | 0.04 [0.03,0.06] | 0.03 [0.02,0.06]] | 0.04 [0.02,0.06] | 0.22 |
IL1β day 3 (CNRQ) | 1.64 [1.11–2.39] | 1.15 [0.87–1.82] | 1.34 [1.05–2.14] | < 0.01* |
Outcomes | ||||
Vasopressors duration (days) | 2.9 [1.8–6.0] | 3.4 [2.1–5.7] | 3.1 [1.9–6.0] | 0.66 |
Hemofiltration duration (days) | 4 [3–10] | 4 [2–6] | 4 [2–7] | 0.55 |
Mechanical ventilation (days) | 9 [7–17] | 11 [8–16] | 11 [7–17] | 0.45 |
ICU length of stay (days) | 13 [9–24] | 16 [10–20] | 14 [9–21] | 0.21 |
Hospital length of stay (days) | 28 [16–53] | 33 [19–59] | 30 [19–54] | 0.44 |
ICU mortality | 11 (24) | 12 (23) | 23 (23) | 1.00 |
Survival D28 | 35 (76) | 42 (81) | 77 (79) | 0.75 |
At least one IAI | 11 (24) | 14 (27) | 25 (26) | 0.91 |