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Intensive Care Medicine Experimental
Fig. 1 | Intensive Care Medicine Experimental

Fig. 1

From: Alleviation of exhaustion-induced immunosuppression and sepsis by immune checkpoint blockers sequentially administered with antibiotics—analysis of a new mathematical model

Fig. 1

A graphical display of Model V1. The model is based on four assumptions: 1. HSCs (H) continually differentiate into myeloid cells (M; neutrophils, macrophages) and lymphocytes (L). 2. The presence of pathogen (P) biases HSC differentiation towards the myeloid lineage. 3. Lymphocytes encounter myeloid cells that have phagocytized antigen, and expand their population in response. 4. Myeloid cells and lymphocytes inhibit pathogen growth. See Additional file 1 for the equations and parameters for Model V1. Regular, blunted, and dashed arrows indicate activation, inhibition, and differentiation, respectively

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