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Fig. 4 | Intensive Care Medicine Experimental

Fig. 4

From: Alleviation of exhaustion-induced immunosuppression and sepsis by immune checkpoint blockers sequentially administered with antibiotics—analysis of a new mathematical model

Fig. 4

Simulation results for model V2. a Mild pathogens (pP = 1) are quickly eliminated. b Moderate pathogens (pP = 1.5) induce regular oscillations of the pathogen with a slowly declining lymphocyte population. c Aggressive pathogens (pP = 2) cause a rapid lymphocyte decline, allowing the pathogen to remain at a constant high level (as opposed to the result in Fig. 2c). Blue, red, and black lines indicate myeloid cells (M), lymphocytes (L), and pathogen (P), respectively

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