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Fig. 6 | Intensive Care Medicine Experimental

Fig. 6

From: Alleviation of exhaustion-induced immunosuppression and sepsis by immune checkpoint blockers sequentially administered with antibiotics—analysis of a new mathematical model

Fig. 6

Simulation results for treatment with different protocols of antibiotics and their combination with immunotherapy. a Targeted antibiotics alone. b Targeted antibiotics followed by immunotherapy after 200 h. c Targeted antibiotics followed by immunotherapy after 100 h. d Targeted antibiotics followed by targeted antibiotics after 250 h. e Targeted antibiotics followed by immunotherapy after 200 h and targeted antibiotics after 250 h. f Targeted antibiotics followed by immunotherapy after 100 h and targeted antibiotics after 250 h. Blue, red, and black lines indicate myeloid cells (M), lymphocytes (L), and pathogen (P), respectively. Dotted vertical lines indicate time of administration of strong targeted antibiotics (reduction of 40% in pathogen growth rate, pP, to 1.2); straight vertical gray lines indicate time of administration of immunotherapy; dashed vertical lines indicate time of administration of weak broad spectrum antibiotics (reduction of 20% in pathogen growth rate, pP, to 1.6)

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