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Fig. 1 | Intensive Care Medicine Experimental

Fig. 1

From: Effect of landiolol on sex-related transcriptomic changes in the myocardium during sepsis

Fig. 1

Differentially expressed genes (DEG) in male and female hearts after cecal ligation and puncture and landiolol. DEG were obtained after 2-class significance analysis of microarrays (SAM) 2 classes in TMeV, 10,000 permutations with an FDR < 0.01 for CLP vs sham (a) and with an FDR < 0.05 for CLP plus landiolol vs CLP groups (b). a, b Venn diagrams show the total number of DEG and the number of genes significantly up- and down-regulated in CLP (a) and CLP plus landiolol groups (b). The number of specific genes in females is very low compared to males. c, d A gene ontology analysis realised with the DAVID Database is reported on graphs in which the most significant biological process (BP)-GO terms for up- and down-regulated genes are indicated for CLP vs sham groups (c) and for CLP plus landiolol vs CLP groups (b). For all the processes, the number of genes deregulated in males is much greater than in females. Note the total absence of significant biological processes for females after landiolol infusion in (d). (*) indicates over-expressed biological processes during CLP that were reversed by landiolol. (§) indicates under-expressed biological processes during CLP that were reversed by landiolol. (#) indicates under-expressed biological processes related to cardiac activity and cardiomyocyte function that were affected during CLP and were not restored by landiolol. (←) shows that the immune response is over-expressed during sepsis and potentiated by landiolol. (N = 5–6 per group). CLP cecal ligation and puncture, CLP + Lnd CLP plus landiolol, Nb of genes number of genes

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