Impact of intensive care unit supportive care on the physiology of Ebola virus disease in a universally lethal non-human primate model

Intensive Care Medicine Experimental

Table 1 Important experimental time points

Time point	NHP1	NHP2	NHP3	NHP4	Average	Standard deviation
Onset of compensated shock	101	115	115	116	111.8	7.2
Onset of decompensated shock	135	147	132	146	140	7.6
Start of fluid resuscitation	135	131	130	134	132.5	2.4
Start of the first vasoactive agent	141.5	144	140	159	146.1	8.7
Average urine output (mL/kg/h)	4.7	5.5	4.9	4.3	4.9	0.5
Start of the second vasoactive agent	143	162	153	172	157.5	12.4
Blood transfusion	145	149	148	145	146.8	2.1
Onset of fever	123	102	Remained afebrile	121	115.3	11.6
Onset of viremia	120*	104	80	100	101	16.5
Time to terminal endpoint	150	166	164	186	166.5	14.8

*Viral load was performed once daily for this animal, leading to probably late detection; see Fig. 3