Fig. 5

Comparison of the course of blood pH (up), HCO₃⁻, and pCO₂ (bottom) during treatments with ADVOS and CVVH. A metabolic acidosis was triggered in blood reaching baseline values before treatment of pH < 7.2, HCO₃⁻ < 14 mmol/l, and pCO₂ of 45 mmHg (preparation phase). Then, for 1 h, either a conventional hemofiltration using a commercially available substitution fluid with 35 mmol/l bicarbonate or a treatment with ADVOS multi with a dialysate pH of 9.00 was performed. Lactic acid was continuously supplied to maintain lactate levels over 5 mmol/l