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Table 1 Experimental setting for each of the tests performed

From: Respiratory and metabolic acidosis correction with the ADVanced Organ Support system

  Set 1 Set 2 Set 3 Set 4 Set 5
Supply
 CO2 (ml/min) (1) (2) 110 110 (1) No 27
 Lactic acid (mmol/min) No (3) No No 0.5 0.5 No
Device settings
 Treatment ADVOS ADVOS ADVOS CVVHD ADVOS CVVH ADVOS
 Blood flow (ml/min) 100, 200, 400 100, 200, 400 400 400 200 200 200
 Single pass dialysate flow (ml/min) n.a. n.a. n.a. 350 n.a. n.a. n.a.
 Recirculating dialysate flow (ml/min)* 800 800 800 n.a. 800 n.a. 800
 Concentrate flow (ml/min)** 160, 320 320 320 n.a. 160 n.a. 160
 Replacement solution flow (ml/min) n.a. n.a. n.a. n.a. n.a. 65 n.a.
 Ultrafiltration flow (ml/min) n.a. n.a. n.a. n.a. n.a. 15 n.a.
 Dialysate/replacement solution pH 7.5, 8.0, 8.5, 9.0, 10.0 7.5, 8.0, 8.5, 9.0 10.0 8.0 9.0 7.4 9.0
 Dialyzer surface (m2) 2 × 1.9 2 × 1.9 2 × 1.9 2.5 2 × 1.9 1.9 2 × 1.9
Alkaline concentrate (during treatment phase) BC-Bic20, BC-Bic0 BC-Bic20 BC-Bic0 n.a. BC-Bic20 n.a. BC-Bic0
Blood baseline levels (before treatment phase)
 pH 7.35–7.45 7.35–7.45 7.35–7.45 7.35–7.45 < 7.15 < 7.15 < 7.15
 pCO2 (mmHg) 35–45 35–45 35–45 35–45 35–45 35–45 > 60
 HCO3 (mmol/l) 22–28 22–28 22–28 22–28 12–14 12–14 > 32
 Lactate (mmol/l) n.a. n.a. n.a. n.a. 5–6 5–6 n.a.
Number of experiments performed*** 3 3 6 6 3 3 2
  1. n.a. not applicable
  2. (1)CO2 supply was adjusted such that blood pH remained between 7.35 and 7.45
  3. (2)CO2 was continuously infused on demand to maintain pCO2 levels between 35 and 45 mmHg
  4. (3)A continuous 2% lactic acid solution was infused such that blood pH remained between 7.35 and 7.45
  5. *The recirculating dialysate flow in the ADVOS system reflects the volume of dialysate that recirculates continuously (not discarded)
  6. **The concentrate flow corresponds to the dialysate flow of a conventional single pass dialysis device and reflects the amount of dialysate used and discarded
  7. ***Experiments performed with each combination of blood flow, concentrate flow, and dialysate pH