Table 1 Experimental setting for each of the tests performed
From: Respiratory and metabolic acidosis correction with the ADVanced Organ Support system
Set 1 | Set 2 | Set 3 | Set 4 | Set 5 | |||
|---|---|---|---|---|---|---|---|
Supply | |||||||
CO2 (ml/min) | (1) | (2) | 110 | 110 | (1) | No | 27 |
Lactic acid (mmol/min) | No | (3) | No | No | 0.5 | 0.5 | No |
Device settings | |||||||
Treatment | ADVOS | ADVOS | ADVOS | CVVHD | ADVOS | CVVH | ADVOS |
Blood flow (ml/min) | 100, 200, 400 | 100, 200, 400 | 400 | 400 | 200 | 200 | 200 |
Single pass dialysate flow (ml/min) | n.a. | n.a. | n.a. | 350 | n.a. | n.a. | n.a. |
Recirculating dialysate flow (ml/min)* | 800 | 800 | 800 | n.a. | 800 | n.a. | 800 |
Concentrate flow (ml/min)** | 160, 320 | 320 | 320 | n.a. | 160 | n.a. | 160 |
Replacement solution flow (ml/min) | n.a. | n.a. | n.a. | n.a. | n.a. | 65 | n.a. |
Ultrafiltration flow (ml/min) | n.a. | n.a. | n.a. | n.a. | n.a. | 15 | n.a. |
Dialysate/replacement solution pH | 7.5, 8.0, 8.5, 9.0, 10.0 | 7.5, 8.0, 8.5, 9.0 | 10.0 | 8.0 | 9.0 | 7.4 | 9.0 |
Dialyzer surface (m2) | 2 × 1.9 | 2 × 1.9 | 2 × 1.9 | 2.5 | 2 × 1.9 | 1.9 | 2 × 1.9 |
Alkaline concentrate (during treatment phase) | BC-Bic20, BC-Bic0 | BC-Bic20 | BC-Bic0 | n.a. | BC-Bic20 | n.a. | BC-Bic0 |
Blood baseline levels (before treatment phase) | |||||||
pH | 7.35–7.45 | 7.35–7.45 | 7.35–7.45 | 7.35–7.45 | < 7.15 | < 7.15 | < 7.15 |
pCO2 (mmHg) | 35–45 | 35–45 | 35–45 | 35–45 | 35–45 | 35–45 | > 60 |
HCO3− (mmol/l) | 22–28 | 22–28 | 22–28 | 22–28 | 12–14 | 12–14 | > 32 |
Lactate (mmol/l) | n.a. | n.a. | n.a. | n.a. | 5–6 | 5–6 | n.a. |
Number of experiments performed*** | 3 | 3 | 6 | 6 | 3 | 3 | 2 |