Increased mortality in elderly patients with acute respiratory distress syndrome is not explained by host response

Intensive Care Medicine Experimental

Table 2 Association between age and mortality in ARDS patients (mediation step 1)

	Crude odds ratio [95% CI]	p value	Adjusted odds ratio [95% CI]^‡	p value	GOF p value
90-day mortality
Young adults	Reference	NA	Reference	NA	0.153
Middle-aged adults	1.3 [0.9, 2.0]	0.159	1.5 [1.0, 2.3]	0.078
Elderly	1.7 [1.2, 2.6]	0.008	2.1 [1.4, 3.4]	0.001
30-day mortality
Young adults	Reference	NA	Reference	NA	0.081
Middle-aged adults	1.1 [0.7, 1.7]	0.740	1.2 [0.8, 1.9]	0.469
Elderly	1.3 [0.8, 2.0]	0.240	1.5 [0.9, 2.4]	0.096
1-year mortality
Young adults	Reference	NA	Reference	NA	0.716
Middle-aged adults	1.5 [1.0, 2.2]	0.035	1.7 [1.1, 2.6]	0.016
Elderly	2.0 [1.4, 3.0]	0.000	2.4 [1.6, 3.8]	0.000

Data is presented as odds ratio’s (OR) with a 95% confidence interval [CI]. ^‡Adjusted for ethnic background, gender, admission type, readmission, direct hit for ARDS, Charlson Comorbidity Index, APACHE-IV score adjusted for age, immunodeficiency, tidal volume per predicted body weight, and positive end-expiratory pressure. A p value < 0.05 was considered as statistically significant. GOF goodness of fit, omnibus test, a p value of < 0.05 is considered as a lack of fit. NA not applicable