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Table 1 Respiratory mechanics

From: Increased effort during partial ventilatory support is not associated with lung damage in experimental acute lung injury

  PC (n = 9) AC (n = 10) PS100 (n = 9) PS60 (n = 10) PS20 (n = 10) Main effect
Within group Between group
PAW [cmH2O] BL 15 ± 3 15 ± 4 13 ± 2 14 ± 3 13 ± 1   
ALI-BL 22 ± 4 22 ± 4 18 ± 3 20 ± 4 21 ± 1   
ALI-End 26 ± 6#* 25 ± 7 19 ± 7 15 ± 5* 9 ± 3#* 0.060 0.000
PTPinsp [cmH2O] BL 16 ± 4 15 ± 4 13 ± 4 14 ± 4 13 ± 5   
ALI-BL 22 ± 5 23 ± 4 20 ± 6 19 ± 6 19 ± 4   
ALI-End 25 ± 7 26 ± 7 24 ± 9 23 ± 6 23 ± 8 0.006 0.987
PTPexp [cmH2O] BL 5 ± 3 4 ± 2 4 ± 3 6 ± 2 4 ± 4   
ALI-BL 4 ± 3 5 ± 2 6 ± 5 4 ± 3 3 ± 3   
ALI-End 5 ± 4 5 ± 4 6 ± 4 4 ± 2 3 ± 6 0.790 0.337
VT [ml/kg BW] BL 9.6 ± 1.2 8.7 ± 0.8 8.7 ± 0.6 8.8 ± 1 8.6 ± 0.9   
ALI-BL 8.4 ± 1.6 9.4 ± 2.0 8.9 ± 2.8 11 ± 4 8.6 ± 1.9   
ALI-End 9.0 ± 1.2 9.0 ± 1.2 9.1 ± 1.0 10 ± 3 8.9 ± 1.2 0.919 0.853
RR [min−1] BL 77 ± 18 81 ± 15 84 ± 8 87 ± 7 85 ± 9   
ALI-BL 75 ± 17 82 ± 14 85 ± 11 92 ± 6 84 ± 11   
ALI-End 86 ± 16# 94 ± 17# 71 ± 31 77 ± 17# 80 ± 20 0.213 0.011
VE [ml/min] BL 334 ± 115 328 ± 68 348 ± 42 353 ± 56 339 ± 48   
ALI-BL 323 ± 60 346 ± 86 364 ± 82 403 ± 91 352 ± 58   
ALI-End 318 ± 70 411 ± 117 320 ± 115 396 ± 123 330 ± 130 0.662 0.345
  1. BL baseline measurement on pressure controlled ventilation, ALI-BL measurement on pressure-controlled ventilation after induction of lung injury, ALI-End last measurement after 2–4 h of experimental ventilation mode, PAW peak airway pressure, PTPi peak inspiratory transpulmonary pressure, VT tidal volume, RR respiratory rate, VE minute ventilation, *p < 0.05 vs. other groups #p < 0.05 vs. ALI-BL