Increased effort during partial ventilatory support is not associated with lung damage in experimental acute lung injury

Intensive Care Medicine Experimental

Table 1 Respiratory mechanics

		PC (n = 9)	AC (n = 10)	PS100 (n = 9)	PS60 (n = 10)	PS20 (n = 10)	Main effect
		PC (n = 9)	AC (n = 10)	PS100 (n = 9)	PS60 (n = 10)	PS20 (n = 10)	Within group	Between group
P_AW [cmH₂O]	BL	15 ± 3	15 ± 4	13 ± 2	14 ± 3	13 ± 1
	ALI-BL	22 ± 4	22 ± 4	18 ± 3	20 ± 4	21 ± 1
	ALI-End	26 ± 6#*	25 ± 7	19 ± 7	15 ± 5*	9 ± 3#*	0.060	0.000
P_TPinsp [cmH₂O]	BL	16 ± 4	15 ± 4	13 ± 4	14 ± 4	13 ± 5
	ALI-BL	22 ± 5	23 ± 4	20 ± 6	19 ± 6	19 ± 4
	ALI-End	25 ± 7	26 ± 7	24 ± 9	23 ± 6	23 ± 8	0.006	0.987
P_TPexp [cmH₂O]	BL	5 ± 3	4 ± 2	4 ± 3	6 ± 2	4 ± 4
	ALI-BL	4 ± 3	5 ± 2	6 ± 5	4 ± 3	3 ± 3
	ALI-End	5 ± 4	5 ± 4	6 ± 4	4 ± 2	3 ± 6	0.790	0.337
V_T [ml/kg BW]	BL	9.6 ± 1.2	8.7 ± 0.8	8.7 ± 0.6	8.8 ± 1	8.6 ± 0.9
	ALI-BL	8.4 ± 1.6	9.4 ± 2.0	8.9 ± 2.8	11 ± 4	8.6 ± 1.9
	ALI-End	9.0 ± 1.2	9.0 ± 1.2	9.1 ± 1.0	10 ± 3	8.9 ± 1.2	0.919	0.853
RR [min⁻¹]	BL	77 ± 18	81 ± 15	84 ± 8	87 ± 7	85 ± 9
	ALI-BL	75 ± 17	82 ± 14	85 ± 11	92 ± 6	84 ± 11
	ALI-End	86 ± 16#	94 ± 17#	71 ± 31	77 ± 17#	80 ± 20	0.213	0.011
V_E [ml/min]	BL	334 ± 115	328 ± 68	348 ± 42	353 ± 56	339 ± 48
	ALI-BL	323 ± 60	346 ± 86	364 ± 82	403 ± 91	352 ± 58
	ALI-End	318 ± 70	411 ± 117	320 ± 115	396 ± 123	330 ± 130	0.662	0.345

BL baseline measurement on pressure controlled ventilation, ALI-BL measurement on pressure-controlled ventilation after induction of lung injury, ALI-End last measurement after 2–4 h of experimental ventilation mode, P_AW peak airway pressure, P_TPi peak inspiratory transpulmonary pressure, V_T tidal volume, RR respiratory rate, V_E minute ventilation, *p < 0.05 vs. other groups #p < 0.05 vs. ALI-BL