| |
PC (n = 9)
|
AC (n = 10)
|
PS100 (n = 9)
|
PS60 (n = 10)
|
PS20 (n = 10)
|
Main effect
|
|---|
|
Within group
|
Between group
|
|---|
|
PAW [cmH2O]
|
BL
|
15 ± 3
|
15 ± 4
|
13 ± 2
|
14 ± 3
|
13 ± 1
| | |
|
ALI-BL
|
22 ± 4
|
22 ± 4
|
18 ± 3
|
20 ± 4
|
21 ± 1
| | |
|
ALI-End
|
26 ± 6#*
|
25 ± 7
|
19 ± 7
|
15 ± 5*
|
9 ± 3#*
|
0.060
|
0.000
|
|
PTPinsp [cmH2O]
|
BL
|
16 ± 4
|
15 ± 4
|
13 ± 4
|
14 ± 4
|
13 ± 5
| | |
|
ALI-BL
|
22 ± 5
|
23 ± 4
|
20 ± 6
|
19 ± 6
|
19 ± 4
| | |
|
ALI-End
|
25 ± 7
|
26 ± 7
|
24 ± 9
|
23 ± 6
|
23 ± 8
|
0.006
|
0.987
|
|
PTPexp [cmH2O]
|
BL
|
5 ± 3
|
4 ± 2
|
4 ± 3
|
6 ± 2
|
4 ± 4
| | |
|
ALI-BL
|
4 ± 3
|
5 ± 2
|
6 ± 5
|
4 ± 3
|
3 ± 3
| | |
|
ALI-End
|
5 ± 4
|
5 ± 4
|
6 ± 4
|
4 ± 2
|
3 ± 6
|
0.790
|
0.337
|
|
VT [ml/kg BW]
|
BL
|
9.6 ± 1.2
|
8.7 ± 0.8
|
8.7 ± 0.6
|
8.8 ± 1
|
8.6 ± 0.9
| | |
|
ALI-BL
|
8.4 ± 1.6
|
9.4 ± 2.0
|
8.9 ± 2.8
|
11 ± 4
|
8.6 ± 1.9
| | |
|
ALI-End
|
9.0 ± 1.2
|
9.0 ± 1.2
|
9.1 ± 1.0
|
10 ± 3
|
8.9 ± 1.2
|
0.919
|
0.853
|
|
RR [min−1]
|
BL
|
77 ± 18
|
81 ± 15
|
84 ± 8
|
87 ± 7
|
85 ± 9
| | |
|
ALI-BL
|
75 ± 17
|
82 ± 14
|
85 ± 11
|
92 ± 6
|
84 ± 11
| | |
|
ALI-End
|
86 ± 16#
|
94 ± 17#
|
71 ± 31
|
77 ± 17#
|
80 ± 20
|
0.213
|
0.011
|
|
VE [ml/min]
|
BL
|
334 ± 115
|
328 ± 68
|
348 ± 42
|
353 ± 56
|
339 ± 48
| | |
|
ALI-BL
|
323 ± 60
|
346 ± 86
|
364 ± 82
|
403 ± 91
|
352 ± 58
| | |
|
ALI-End
|
318 ± 70
|
411 ± 117
|
320 ± 115
|
396 ± 123
|
330 ± 130
|
0.662
|
0.345
|
- BL baseline measurement on pressure controlled ventilation, ALI-BL measurement on pressure-controlled ventilation after induction of lung injury, ALI-End last measurement after 2–4 h of experimental ventilation mode, PAW peak airway pressure, PTPi peak inspiratory transpulmonary pressure, VT tidal volume, RR respiratory rate, VE minute ventilation, *p < 0.05 vs. other groups #p < 0.05 vs. ALI-BL
