| |
PC (n = 9)
|
AC (n = 10)
|
PS100 (n = 9)
|
PS60 (n = 10)
|
PS20 (n = 10)
|
Main effect
|
|---|
|
Within group
|
Between group
|
|---|
|
HR [min−1]
|
BL
|
420 ± 33
|
394 ± 43
|
388 ± 90
|
405 ± 32
|
370 ± 36
| | |
|
ALI-BL
|
377 ± 65
|
382 ± 45
|
374 ± 53
|
375 ± 65
|
410 ± 41
| | |
|
ALI-End
|
357 ± 96
|
324 ± 67#
|
353 ± 64
|
342 ± 39
|
375 ± 42#
|
0.005
|
0.830
|
|
MAP [mmHg]
|
BL
|
139 ± 26
|
134 ± 32
|
152 ± 15
|
150 ± 16
|
147 ± 23
| | |
|
ALI-BL
|
101 ± 37
|
120 ± 24
|
124 ± 22
|
125 ± 23
|
124 ± 24
| | |
|
ALI-End
|
47 ± 40#
|
74 ± 44#
|
80 ± 16#
|
78 ± 26#
|
72 ± 35#
|
0.000
|
0.943
|
|
CO [ml/min]
|
BL
|
116 ± 44
|
107 ± 27
|
128 ± 24
|
130 ± 27
|
124 ± 26
| | |
|
ALI-BL
|
92 ± 29
|
103 ± 17
|
147 ± 30
|
129 ± 18
|
146 ± 41
| | |
|
ALI-End
|
128 ± 47
|
91 ± 52
|
130 ± 29
|
132 ± 29
|
113 ± 42
|
0.575
|
0.139
|
|
pHa
|
BL
|
7.26 ± 0.09
|
7.26 ± 0.06
|
7.25 ± 0.08
|
7.25 ± 0.07
|
7.28 ± 0.05
| | |
|
ALI-BL
|
7.22 ± 0.11
|
7.23 ± 0.07
|
7.22 ± 0.06
|
7.24 ± 0.07
|
7.22 ± 0.05
| | |
|
ALI-End
|
7.07 ± 0.12#
|
7.08 ± 0.15#
|
7.04 ± 0.19#
|
7.13 ± 0.15#
|
7.04 ± 0.09#
|
0.000
|
0.763
|
|
PaO2 [torr]
|
BL
|
445 ± 78
|
440 ± 76
|
451 ± 85
|
448 ± 84
|
450 ± 67
| | |
|
ALI-BL
|
204 ± 119
|
234 ± 105
|
271 ± 91
|
243 ± 73
|
240 ± 62
| | |
|
ALI-End
|
92 ± 50#
|
118 ± 108#
|
166 ± 126#
|
106 ± 67#
|
83 ± 64#
|
0.000
|
0.873
|
|
PaCO2 [torr]
|
BL
|
59 ± 19
|
59 ± 10
|
59 ± 14
|
59 ± 10
|
57 ± 11
| | |
|
ALI-BL
|
60 ± 14
|
57 ± 14
|
61 ± 13
|
61 ± 14
|
65 ± 11
| | |
|
ALI-End
|
74 ± 27
|
68 ± 24
|
78 ± 19#
|
79 ± 26#
|
87 ± 20#
|
0.000
|
0.734
|
- BL baseline measurement on pressure controlled ventilation, ALI-BL measurement on pressure-controlled ventilation after induction of lung injury. Blood gas analyses performed with FiO2 = 1.0. ALI-End last measurement after 2–4 h of experimental ventilation mode, HR heart rate, MAP mean arterial pressure, CO cardiac output, *p < 0.05 vs. other groups #p < 0.05 vs. ALI-BL
