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Table 2 Hemodynamics and gas exchange

From: Increased effort during partial ventilatory support is not associated with lung damage in experimental acute lung injury

  PC (n = 9) AC (n = 10) PS100 (n = 9) PS60 (n = 10) PS20 (n = 10) Main effect
Within group Between group
HR [min−1] BL 420 ± 33 394 ± 43 388 ± 90 405 ± 32 370 ± 36   
ALI-BL 377 ± 65 382 ± 45 374 ± 53 375 ± 65 410 ± 41   
ALI-End 357 ± 96 324 ± 67# 353 ± 64 342 ± 39 375 ± 42# 0.005 0.830
MAP [mmHg] BL 139 ± 26 134 ± 32 152 ± 15 150 ± 16 147 ± 23   
ALI-BL 101 ± 37 120 ± 24 124 ± 22 125 ± 23 124 ± 24   
ALI-End 47 ± 40# 74 ± 44# 80 ± 16# 78 ± 26# 72 ± 35# 0.000 0.943
CO [ml/min] BL 116 ± 44 107 ± 27 128 ± 24 130 ± 27 124 ± 26   
ALI-BL 92 ± 29 103 ± 17 147 ± 30 129 ± 18 146 ± 41   
ALI-End 128 ± 47 91 ± 52 130 ± 29 132 ± 29 113 ± 42 0.575 0.139
pHa BL 7.26 ± 0.09 7.26 ± 0.06 7.25 ± 0.08 7.25 ± 0.07 7.28 ± 0.05   
ALI-BL 7.22 ± 0.11 7.23 ± 0.07 7.22 ± 0.06 7.24 ± 0.07 7.22 ± 0.05   
ALI-End 7.07 ± 0.12# 7.08 ± 0.15# 7.04 ± 0.19# 7.13 ± 0.15# 7.04 ± 0.09# 0.000 0.763
PaO2 [torr] BL 445 ± 78 440 ± 76 451 ± 85 448 ± 84 450 ± 67   
ALI-BL 204 ± 119 234 ± 105 271 ± 91 243 ± 73 240 ± 62   
ALI-End 92 ± 50# 118 ± 108# 166 ± 126# 106 ± 67# 83 ± 64# 0.000 0.873
PaCO2 [torr] BL 59 ± 19 59 ± 10 59 ± 14 59 ± 10 57 ± 11   
ALI-BL 60 ± 14 57 ± 14 61 ± 13 61 ± 14 65 ± 11   
ALI-End 74 ± 27 68 ± 24 78 ± 19# 79 ± 26# 87 ± 20# 0.000 0.734
  1. BL baseline measurement on pressure controlled ventilation, ALI-BL measurement on pressure-controlled ventilation after induction of lung injury. Blood gas analyses performed with FiO2 = 1.0. ALI-End last measurement after 2–4 h of experimental ventilation mode, HR heart rate, MAP mean arterial pressure, CO cardiac output, *p < 0.05 vs. other groups #p < 0.05 vs. ALI-BL