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Table 1 General physiological and biochemical variables doing hemorrhagic shock. N = 9. Data are expressed as median levels (interquartile range) during the experimental protocol intervals A, B, and C. MAP mean arterial pressure, ICP intracranial pressure, CPP cerebral perfusion pressure, PbtO2 brain tissue oxygenation. S indicates start of hemorrhage. Time 0 indicates achievement of MAP equal 40 mmHg. Test statistics made with mixed effect model

From: Moderately prolonged permissive hypotension results in reversible metabolic perturbation evaluated by intracerebral microdialysis - an experimental animal study

Elapsed time (min)

Baseline phase

Interval A

(− 60)–0 min

Shock and resuscitation phase

Interval B

0–70 min

Observational phase

Interval C

70–220 min

Interval A versus interval C

p value

MAP (mmHg)

95 (66–107)

39 (35–42)

76 (67–84)

p < 0.005*

ICP (mmHg)

8 (6.5–11)

6 (5–9)

10 (7–14)

p = 0.089

CPP (mmHg)

84 (60–97.5)

33 (28–39)

65 (53–79.5)

p < 0.005 *

PbtO2 (kPa)

29 (24–32)

19 (8–23)

35 (20–45)

p < 0.005*

PaO2 (kPa)

24 (22–26)

24 (23–25)

22 (22–24)

p = 0.002*

PaCO2 (kPa)

5.4 (5,5–89)

5.1 (4,7–5.6)

6.1 (5.7–6.7)

p = 0.025*

b-hemoglobin (mM/L)

8.6 (5.8–9.8)

7.9 (5.2–8.8)

7.8 (6–9.3)

p = 0.084

HR (bpm)

80 (71–92)

125 (82–152)

81 (72–92)

p = 0.502

b-Glucose (mM/L)

5.5 (4.3–7.2)

6.3 (4.2–9.8)

5.3 (4.1–6.9)

p = 0.010*

b-lactate (mM/L)

0.9 (0.5–1.2)

4.3 (2.5–7.3)

1.8 (0.9–5.1)

p = 0.009*

b-pH

7.47 (7.45–7.51)

7.44 (7.39–7.44)

7.40 (7.32–7.46)

p = 0.249

Diuresis (mL)

55 (10–160)

3 (0–12)

19 (6–32)

p < 0.005*

  1. *Statistical significant p value < 0.05