Table 2 Biochemical variables obtained from microdialysis. N = 9. Data expressed as (interquartile range) during the experimental protocol intervals A, B, and C. LP lactate/pyruvate ratio. S indicates start of hemorrhage. Time 0 indicates achievement of MAP equal 40 mmHg. Test statistics made with mixed effect model
Elapsed time (min) | Location | Baseline phase Interval A (− 60)–0 min | Shock and resuscitation phase Interval B 0–70 min | Observational phase Interval C 70–220 min | Interval A versus interval C p value |
|---|---|---|---|---|---|
LP ratio | Hemisph. | 13 (8–16) | 19 (12–30) | 16 (10–23) | 0.020* |
Sag. sinus | 9 (6–22) | 22 (19–26) | 17 (10–27) | 0.012* | |
Femoral | 21 (18–24) | 28 (20–35) | 17 (15–25) | 0.467 | |
Lactate (mM/L) | Hemisph. | 2.3 (1.3–3.0) | 3.2 (2.5–6.1) | 3 (2.3–4.5) | 0.000* |
Sag. sinus | 0.9 (0.3–2.5) | 4.7 (3.4–6.3) | 2.6 (1.1–5.4) | 0.002* | |
Femoral | 1.1 (0.8–1.8) | 4.6 (1.6–6.1) | 1.7 (0.8–3.9) | 0.009* | |
Pyruvate (mM/L) | Hemisph. | 142 (98–203) | 147 (120–261) | 156 (127–249) | 0.000* |
Sag. sinus | 109 (48–151) | 197 (187–313) | 153 (113–201) | 0.003* | |
Femoral | 55 (44–75) | 151 (45–198) | 94 (53–154) | 0.000* | |
Glucose (mM/L) | Hemisph. | 2.2 (1.8–3) | 1.8 (1.4–3.1) | 2.5 (2–3.5) | 0.031* |
Sag. sinus | 1.9 (1–3) | 3.5 (2.4–5.1) | 3.5 (2.3–4.5) | 0.000* | |
Femoral | 4.9 (3.4–5.6) | 6 (4.9–7.3) | 5.5 (4.6–7.1) | 0.010* | |
Glutamate (μM/L) | Hemisph. | 15 (4–22) | 12 (5–14) | 8 (3–11) | 0.050 |
Sag. sinus | 121 (60–178) | 115 (94–176) | 177 (110–195) | 0.011* | |
Femoral | 195 (172–205) | 190 (184–196) | 183 (173–231) | 0.181 | |
Glycerol (μM/L) | Hemisph. | 38 (25–88) | 59 (35–116) | 77 (58–125) | 0.000* |
Sag. sinus | 21 (7–55) | 69 (43–130) | 61 (34–123) | 0.006* | |
Femoral | 15 (12–28) | 47 (22–174) | 46 (30–209) | 0.000* |