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Table 1 Type of studies and main animal characteristics (sorted by animal type)

From: Heart failure supported by veno-arterial extracorporeal membrane oxygenation (ECMO): a systematic review of pre-clinical models

Study Year Species Study type Animal agea Number Heart failure model ECMO configuration Group(s)
Sakamoto et al. 2015 Dogs Other Adult 21 Myocardial infarction Vj-Af ECMO with AMI (n = 13)
ECMO without cardiac failure (n = 8)
Kawashima et al. 2011 Dogs Physiological Adult 6 Myocardial infarction RA-Af
Yu et al. 2008 Dogs Interventional ND 13 Myocardial infarction RA-Af Pulsatile ECMO (n = 7)
Non-pulsatile ECMO (n = 6)
Segesser et al. 2008 Ox Physiological ND 5 Pacing Vf and Pb – ACAR
Møller-Helgestad et al. 2018 Pigs Interventional ND 14 Myocardial infarction Vf-Af ECMO (n = 6)
Impella (n = 6)
Ostadal et al. 2018 Pigs Physiological 4-5 months 16 Myocardial hypoxia Vf-Af
Simonsen et al. 2018 Pigs Interventional 90 days 12 Carbon monoxide poisoning Vf-Af ECMO (n = 6)
Conventional treatment (n = 6)
Janak et al. 2017 Pigs Physiological 4-5 months 8 Myocardial infarction Vf-Af
Vanhuyse et al. 2017 Pigs Interventional ND 12 Myocardial infarction Vf-Af ECMO + normothermia (n = 6)
ECMO + hypothermia (n = 6)
Esposito et al. 2016 Pigs Interventional Adult 10 Myocardial infarction Vf-Af ECMO (n = 4)
TandemHeart (n = 4)
Hala et al. 2016 Pigs Physiological Up to 6 months 5 Pacing Vf-Af
Itoh et al. 2015 Pigs Interventional ND 14 Pacing RA-AO Pulsatile ECMO (n = 7)
Non-pulsatile ECMO (n = 7)
Ostadal et al. 2015 Pigs Physiological 4-5 months 5 Myocardial hypoxia Vf-Af
Brehm et al. 2014 Pigs Physiological ND 7 Drug-induced (Esmolol) Vf-Af
Kajimoto et al. 2014 Pigs Interventional 30-57 days 19 Myocardial infarction RA-AO ECMO with AMI (n = 6)
ECMO with AMI and T3 supplementation (n = 6)
ECMO without cardiac failure (n = 5)
Zhu et al. 2014 Pigs Interventional 4-5 months 24 Myocardial infarction Vf-Af ECMO (n = 8)
Control/sham (n = 8)
Drug therapy (n = 8)
Bartoli et al. 2013 Pigs Interventional ND 47 Myocardial infarction Vj-AAOc ECMO vs IABP (n = 10)
ECMO vs PFVAD (n = 10)
ECMO vs CFVAD (n = 6)
Sauren et al. 2007 Sheep Physiological ND 7 Myocardial infarction Vf-Af and Vf-AO
Naito et al. 2017 Sheep Physiological Adult 6 Drug-induced (esmolol) Vj-AAOc
  1. AMI acute myocardial infarction; Af femoral artery; AO aorta; AR right atrium; asc. ascending; CAR carotid artery; CFVAD continuous-flow ventricular assist device; P pulmonary artery; PFVAD pulsatile-flow ventricular assist device; Vf femoral vein; Vj jugular vein
  2. aAnimal age is written as per original paper statement
  3. bVenous canula was first inserted into the right atrium through femoral access (as per peripheral VA-ECMO) and then pushed onto the left pulmonary artery; arterial canula was maintained in the carotid throughout the experiment (as per pediatric ECMO configuration)
  4. cArterial canula was inserted surgically directly into the abdominal aorta through a graft