Dataset | Example items | Notes/criteria proposed |
---|---|---|
1. Animal | Species, age, sex, housing and husbandry. | Use ARRIVE guidelines [12] |
2. Heart failure model | Method of injury including detailed surgical/medical procedure, timing and delay Heart failure/cardiogenic shock definition Heart failure/cardiogenic shock achievement | Use latest guidelines and/or trials adapted to fit with animal practice |
3. Hemodynamic | Hemodynamic targets | MAP > 65 mmHg, arterial lactate < 2 mmol/L Items mandatory to report: LVOT VTI, LVEF, aortic valve opening, pulse pressure |
Hemodynamic support strategy | Fluid support (type and volume per kg) and strategy Vasopressor support (type and dose per kg per min) and strategy (first line support, second line support) | |
4. ECMO type | ECMO configuration Method of cannulation | Peripheral (except in post-cardiotomy setting) Percutaneous femoral access (except in post-cardiotomy setting) |
5. ECMO equipment | Pump and oxygenator model Canula model and size Placement confirmation (if peripheral) | Use Maastricht treaty nomenclature [9] |
6. ECMO settings | Flow targets Gas exchange targets Anticoagulation treatment and target | 60-80 mL/kg/min FmO2 minimal, sweep gas flow to maintain stable pH |