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Table 5 Proposed minimum reporting dataset for pre-clinical models of heart failure supported by VA-ECMO

From: Heart failure supported by veno-arterial extracorporeal membrane oxygenation (ECMO): a systematic review of pre-clinical models

Dataset Example items Notes/criteria proposed
1. Animal Species, age, sex, housing and husbandry. Use ARRIVE guidelines [12]
2. Heart failure model Method of injury including detailed surgical/medical procedure, timing and delay
Heart failure/cardiogenic shock definition
Heart failure/cardiogenic shock achievement
Use latest guidelines and/or trials adapted to fit with animal practice
3. Hemodynamic Hemodynamic targets MAP > 65 mmHg, arterial lactate < 2 mmol/L
Items mandatory to report: LVOT VTI, LVEF, aortic valve opening, pulse pressure
Hemodynamic support strategy Fluid support (type and volume per kg) and strategy
Vasopressor support (type and dose per kg per min) and strategy (first line support, second line support)
4. ECMO type ECMO configuration
Method of cannulation
Peripheral (except in post-cardiotomy setting)
Percutaneous femoral access (except in post-cardiotomy setting)
5. ECMO equipment Pump and oxygenator model
Canula model and size
Placement confirmation (if peripheral)
Use Maastricht treaty nomenclature [9]
6. ECMO settings Flow targets
Gas exchange targets
Anticoagulation treatment and target
60-80 mL/kg/min
FmO2 minimal, sweep gas flow to maintain stable pH
  1. ECMO extracorporeal membrane oxygenation; FmO2 membrane fraction of oxygen; LVEF left ventricular ejection fraction; LVOT left ventricular outflow tract; MAP mean arterial pressure; SvO2 venous saturation of oxygen; VTI velocity-time index