Table 1 Suggestions to improve translational study design in critical care
From: The importance of discovery science in the development of therapies for the critically ill
Improving preclinical models | Use of multiple hits |
Incorporate frailty | |
Extended duration of models | |
Multi-center approach | |
Use of randomization | |
Bench to bedside communication of phenotype discovery | |
Improving clinical trials | Mechanistic substudies |
Bedside to bench communication of phenotype discovery | |
Testing of pharmacologic strategies in biologically homogenous patient subsets with activation of relevant pathways |