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Table 2 Cellular lineages and characteristic surface markers of frequent circulating and urinary EVs

From: Extracellular vesicles as regulators of kidney function and disease

Compartment

EV population

Parent cell

EV surface markers

Blood

EC-EVs

Endothelial cells

CD31, CD34, CD62E, CD105, CD106, CD142, CD144, CD146

leu-EVs

â–ª B-EVs

â–ª Mo-EVs

â–ª PMN-EVs

- Nφ-EVs

â–ª T-EVs

Leukocytes

â–ª B lymphocytes

â–ª monocytes

â–ª granulocytes

- neutrophils

â–ª T lymphocytes

CD11a, CD18, CD45

â–ª CD19, CD20

â–ª CD14, CD16, CD33, CD64, CD142

â–ª CD11b, CD15

- CD16, CD66b

â–ª CD3, CD4, CD8

plt-EVs

Platelets

CD31, CD41a, CD42a, CD42b, CD61, CD62P

RBC-EVs

Erythrocytes

CD35, CD235a, CD235b

Urine

Pod-EVs

Podocytes

KIRREL (NEPH1), Nephrin, Podocalyxin, Podocin (NEPH2)

TEC-EVs

Tubular epithelial cells

Aquaporin 1 (AQP1), CD10, CD13, Uromodulin (Tamm Horsfall Glykoprotein)

CDEC-EVs

Collecting duct epithelial cells

Aquaporin 2 (AQP2)