From: Extracellular vesicles as regulators of kidney function and disease
Condition | EV populations and cargoa | Functionb |
---|---|---|
CVVH | Ultrafiltrate: no EVs [109] pre- vs. post-filter: total EVs →, CD31+/CD41- EVs ↑ (sepsis-AKI) [109] |  |
HD | Ultrafiltrate/dialysate: only traces of miRNA (hence no EVs) [110] pre- vs. post-HD: total plasma miRNA → [110] low flux: EC-EVs and Mo-EVs ↑ after HD compared to high flux [116] | miR-223+ EVs: VSMC calcification ↑, angiogenesis ↓, EC apoptosis ↑ [81] |
HDF | EC-EVs ↓ compared to HD [81, 90, 117] miR-223 ↓ compared to HD [81] | VSMC calcification ↓, angiogenesis ↑, EC apoptosis ↓ compared to HD [81] |
PD | Â |