Intensive Care Medicine Experimental

Table 4 Regional end-expiratory pleural and transpulmonary pressures

From: Comparative effects of flow vs. volume-controlled one-lung ventilation on gas exchange and respiratory system mechanics in pigs

Parameter	Therapy				ANOVA (P=)
Group	Mode	20′	40′	60′	Seq	Group	Mode	Time	Mixed
PPvent (cmH₂O)					0.073	0.994	0.022	0.437	0.116
Norm	VCV	0.1 ± 2.6	− 0.1 ± 2.7	− 0.0 ± 3.2			0.076	0.866	0.256
Norm	FCV	− 1.3 ± 3.6	− 1.0 ± 3.4	− 0.2 ± 3.5
Hypo	VCV	0.3 ± 0.7	− 0.6 ± 2.4	− 0.3 ± 2.9			0.161	0.327	0.288
Hypo	FCV	− 0.7 ± 2.1	− 0.9 ± 3.0	− 0.3 ± 1.7
PPdors (cmH₂O)					0.054	0.079	0.975	0.045	0.744
Norm	VCV	− 1.9 ± 3.1	− 1.5 ± 4.1	0.1 ± 3.0
Norm	FCV	− 1.0 ± 3.1	− 1.6 ± 3.7	− 0.8 ± 2.9
Hypo	VCV	0.9 ± 0.7	0.6 ± 1.5	1.1 ± 0.8
Hypo	FCV	− 0.3 ± 3.2	0.6 ± 0.9	1.1 ± 0.8
PPcaud (cmH₂O)					0.754	0.109	0.211	0.202	0.447
Norm	VCV	− 0.2 ± 3.2	− 0.7 ± 3.5	0.1 ± 3.3
Norm	FCV	− 1.8 ± 4	− 0.8 ± 3.4	− 0.0 ± 3.4
Hypo	VCV	1.0 ± 2.0	1.9 ± 1.4	1.7 ± 1.3
Hypo	FCV	1.3 ± 1.6	1.5 ± 1.4	1.5 ± 1.6
TPvent (cmH₂O)					0.103	0.970	0.262	0.461	0.076
Norm	VCV	5.4 ± 2.5	5.6 ± 2.8	5.4 ± 3.1
Norm	FCV	5.8 ± 3.5	5.3 ± 3.2	4.5 ± 3.2
Hypo	VCV	5.11 ± 0.7	6 ± 2.4	5.7 ± 2.8
Hypo	FCV	5.22 ± 2.2	5.4 ± 3.0	4.8 ± 1.6
TPdors (cmH₂O)					0.092	0.098	0.347	0.036	0.984
Norm	VCV	7.3 ± 3.0	7.0 ± 4.4	5.3 ± 2.8
Norm	FCV	5.8 ± 3.5	5.5 ± 3.2	5 ± 2.7
Hypo	VCV	4.5 ± 0.6	4.8 ± 1.6	4.3 ± 0.8
Hypo	FCV	4.9 ± 2.8	3.9 ± 0.8	3.36 ± 1.3
TPcaud (cmH₂O)					0.626	0.060	0.839	0.311	0.953
Norm	VCV	5.8 ± 3.0	6.1 ± 3.6	5.3 ± 3.2
Norm	FCV	6.6 ± 4.4	6.0 ± 3.9	5.6 ± 4.4
Hypo	VCV	4.4 ± 1.9	3.5 ± 1.3	3.7 ± 1.2
Hypo	FCV	3.2 ± 1.8	3.0 ± 1.6	3.0 ± 2.0

Values in mean ± standard deviation; Statistical P values according to linear mixed-effects repeated measures ANOVA with within subject factors: mode of ventilation (volume or flow-controlled ventilation) and time of therapy in minutes; and between subject factors group of therapy (normovolaemia or hypovolaemia) and randomization sequence (volume or flow-controlled ventilation first). Significance was accepted for P < 0.05. Statistical analysis was performed in R statistical programming language and the package lme4
FCV flow-controlled ventilation, VCV volume-controlled ventilation, PIPvent end-expiratory ventral pleural pressure, PIPdors end-expiratory dorsal pleural pressure, PIPcaud end-expiratory caudal pleural pressure, TPvent end-expiratory ventral transpulmonary pressure, TPdors end-expiratory dorsal transpulmonary pressure, TPcaud end-expiratory caudal transpulmonary pressure

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