Fig. 1

Time course of laboratory findings and treatment milestones during clinical application of the adsorber device after MDMA intoxication. Serum concentrations of interleukin 6 (IL-6), myoglobin, 3,4-methylenedioxymethamphetamine (MDMA), creatinine, sodium, bilirubin, and international normalized ratio (INR), fibrinogen levels, and aspartate amino transferase (AST) activity were repeatedly measured during the clinical course. MELD score (Model of End-Stage Liver Disease) was calculated to assess liver injury (a). Timeline indicating durations of mechanical ventilation (purple), external cooling (mid-blue), continuous renal replacement therapy (CRRT) with CytoSorb (light-blue), and intermittent renal replacement therapy (IRRT, dashed light-blue) (b)