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Intensive Care Medicine Experimental

Table 2 Population kinetic parameters in the final model for infusion experiments conducted in 35 volunteers

From: Water content of the endothelial glycocalyx layer estimated by volume kinetic analysis

 

Covariate

Best estimate

2.5% CI

97.5% CI

CV%

− 2(LL)

Fixed parameters

      

Vc (L)

-

3.12

2.49

3.76

10.4

 

k12 (10−3 min−1)

-

35.4

16.3

54.5

27.5

 

k21 (10−3 min−1)

-

12.8

4.6

21.0

32.7

 

k10 (10−3 min−1)

-

23.2

16.6

29.8

14.5

− 2721

Covariate effect

      

− Vc

Body weight (kg)

1.16

0.14

2.17

44.8

− 2728

− Vc

Infusion rate (mL/min)

0.52

0.28

0.77

23.9

− 2747

Full block model

All the above

    

− 2766

  1. The right column shows how the log likelihood of the model gradually improves (decreases) when a new covariate is added. A reduction by 3.6 points is statistically significant by P < 0.05
  2. CI confidence interval, CV between-subject coefficient of variation, LL log likelihood for the model
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