Water content of the endothelial glycocalyx layer estimated by volume kinetic analysis

Intensive Care Medicine Experimental

Table 3 Population kinetic parameters in the final model for infusion experiments in the extended analysis of 91 volunteers

	Covariate	Best estimate	2.5% CI	97.5% CI	CV%	− 2(LL)
Fixed parameters
V_c (L)	-	3.54	3.14	3.93	5.7
k₁₂ (10⁻³ min⁻¹)	-	73.6	58.7	88.5	10.2
k₂₁ (10⁻³ min⁻¹)	-	59.6	49.9	69.3	8.3
k₁₀ (10⁻³ min⁻¹)	-	20.3	17.4	23.1	7.1	− 4298
k_b (10⁻³ min⁻¹)	-	11.2	8.1	14.3	14.2	− 4399
Covariate effect
V_c	Gender	− 0.33	− 0.48	− 0.19	− 22.2	− 4414
V_c	Infusion rate (mL/min)	0.43	0.24	0.62	22.9	− 4432

Infusion rate is a power model with a mean infusion rate of 58.0 mL/min. Gender is an exponential model where male = 0 and female = 1. The latter becomes (e ^− 0.33). The full block model did not converge to yield 95% CI
CI confidence interval, CV between-subject coefficient of variation, LL log likelihood